Results 41 to 50 of about 4,547,694 (285)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications

Pharmaceutics
Background/Objectives: Quality by Design (QbD) has revolutionized pharmaceutical development by transitioning from reactive quality testing to proactive, science-driven methodologies.
Shiwei Yang, Xingming Hu, Jinmiao Zhu, Bin Zheng, Wenjie Bi, Xiaohong Wang, Jialing Wu, Zimeng Mi, Yifei Wu   +8 more
doaj   +1 more source

Human Perception Measures for Product Design and Development—A Tutorial to Measurement Methods and Analysis

Multimodal Technologies and Interaction, 2017
This tutorial describes the necessary steps for designing and conducting a perception experiment in order to obtain design parameters for human–machine interactions.
Christian Hatzfeld, Manuel Kühner, Stefan Söllner, Tran Quoc Khanh, Mario Kupnik   +4 more
doaj   +1 more source

Sequential design of computer experiments for the estimation of a probability of failure [PDF]

, 2012
This paper deals with the problem of estimating the volume of the excursion set of a function $f:\mathbb{R}^d \to \mathbb{R}$ above a given threshold, under a probability measure on $\mathbb{R}^d$ that is assumed to be known.
A. Arnaud, A. Borri, A. O’Hagan, A.M. Yaglom, B. Echard, B. Echard, B.J. Bichon, C. Currin, C.G. Bucher, D. Ginsbourger, D.A. Berry, D.P. Bertsekas, D.R. Jones, David Ginsbourger, E. Parzen, E. Vazquez, E. Vazquez, E.M. Vestrup, Emmanuel Vazquez, F. Deheeger, F. Fleuret, G.E.P. Box, G.S. Kimeldorf, H. Pradlwarter, H.J. Kushner, J. Mockus, J. Mockus, J. Oakley, J. Oakley, J. Sacks, J. Villemonteix, J.E. Hurtado, J.E. Hurtado, J.L. Loeppky, J.P. Chilès, Julien Bect, L. Schueremans, Ling Li, M. Kennedy, M.J. Bayarri, M.L. Stein, M.R. Rajashekhar, M.S. Handcock, P. Bjerager, P. Ranjan, P.I. Frazier, R. Paulo, R. Rubinstein, S.K. Au, T.J. Santner, V. Picheny, Victor Picheny, W.H. Press, W.J. Welch   +53 more
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

TEACHING SOFTWARE FOR DESIGNING OF EXPERIMENTS (DOE) IN WOODWORKING PROCESSES [PDF]

Pro Ligno, 2015
This paper presents a teaching software that allows students and researchers to understand how passive and active experiments can be made, without making real experiments.
Wilhelm LAURENZI
doaj  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Modelling multi-tier enterprise applications behaviour with design of experiments technique [PDF]

, 2015
Queueing network models are commonly used for performance modelling. However, through application development stage analytical models might not be able to continuously reflect performance, for example due to performance bugs or minor changes in the ...
Jamshidi, P, Ustinova, T
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Optimization of the Tensile Properties of Polymeric Matrix Composites Reinforced with Magnetite Particles by Experimental Design

TecnoLógicas, 2020
A full-factorial 33 experiment was used in this study to determine the optimal values of the tensile properties of three composite materials manufactured based on three polymeric resins: Derakane Momentum epoxy vinyl ester based on bisphenol-A (DM-411 ...
Luis Ángel Lara-González, Wilmar Guillermo-Rodríguez, Yaneth Pineda-Triana, Gabriel Peña-Rodríguez, Hugo Felipe Salazar   +4 more
doaj   +1 more source