Results 41 to 50 of about 168,505,770 (297)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
, 2016 An empirically grounded understanding about which knowledge and skills that are sought from designers is missing for a number of professional subfields of design. This gap in research challenges i) design educators in planning their educational offerings
Person, Oscar +4 more
core +1 more source
Online Design of Experiments in the Relevant Output Range
, 2013 Wir untersuchen state-of-the-art Experiment Designs im Kontext der Modellierung von Verbrennungsmotoren. Wir wiederholen die Eigenschaften der altbekannten minimax/maximin Designs, sowie die auf der Fischer-Informationsmatrix basierenden ...
Jakubek, Stefan +5 more
core +4 more sources
Multimodal Technologies and Interaction, 2017 This tutorial describes the necessary steps for designing and conducting a perception experiment in order to obtain design parameters for human–machine interactions.
Christian Hatzfeld +4 more
doaj +1 more source
Future Hospital Journal, 2015 The report of the Future Hospital Commission of the Royal College of Physicians acknowledges that the principal challenge for health care organisations and professionals responsible for delivering medical services is to accept the fundamental requirement that patients must be treated with compassion, kindness and respect while having their physical and
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The design and analysis of factorial experiments [PDF]
, 1937 Factorial experiments are experiments which include all combinations of several different sets of treatments or "factors." Information is thus simultaneously obtained on the responses to the different factors, and also on the effects of changes in the ...
Yates, F.
core
PharmaceuticsBackground/Objectives: Quality by Design (QbD) has revolutionized pharmaceutical development by transitioning from reactive quality testing to proactive, science-driven methodologies.
Shiwei Yang +8 more
doaj +1 more source