Results 41 to 50 of about 315,391 (267)

The design and analysis of factorial experiments [PDF]

, 1937
Factorial experiments are experiments which include all combinations of several different sets of treatments or "factors." Information is thus simultaneously obtained on the responses to the different factors, and also on the effects of changes in the ...
Yates, F.
core  

Decomposition tables for experiments I. A chain of randomizations

, 2009
One aspect of evaluating the design for an experiment is the discovery of the relationships between subspaces of the data space. Initially we establish the notation and methods for evaluating an experiment with a single randomization.
Bailey, Rosemary Anne, Brien, C. J., R. A. Bailey, C. J. Brien   +3 more
core   +1 more source

Computer‐simulated experiments and computer games: A method of design analysis [PDF]

, 1995
This paper describes a new research programme to design computer‐simulated experiments in the field of fuels and combustion, and describes a method of categorization based on a taxonomy proposed by Gredler.
Jerome J. Leary, Leary, Jerome
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications

Pharmaceutics
Background/Objectives: Quality by Design (QbD) has revolutionized pharmaceutical development by transitioning from reactive quality testing to proactive, science-driven methodologies.
Shiwei Yang, Xingming Hu, Jinmiao Zhu, Bin Zheng, Wenjie Bi, Xiaohong Wang, Jialing Wu, Zimeng Mi, Yifei Wu   +8 more
doaj   +1 more source

Design of experiments for non-manufacturing processes : benefits, challenges and some examples [PDF]

, 2010
Design of Experiments (DoE) is a powerful technique for process optimization that has been widely deployed in almost all types of manufacturing processes and is used extensively in product and process design and development.
Montgomery, D. C., D C Montgomery, J Antony, M J Anderson, Anderson, M. J., Coleman, S, S Coleman, Anderson, M, Antony, Jiju, Silvestrini, R. T., R T Silvestrini, D. C. Montgomery, Coleman, Shirley, Antony, J., Montgomery, Douglas C, J. Antony, Johnson, Rachel T., Coleman, S., Anderson, Mark J., Montgomery, Douglas C., R. T. Silvestrini, Silvestrini, R T, S. Coleman, M. J. Anderson   +23 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Physiological measurements of drawing and forming activities [PDF]

, 2016
The embodiment of tools and experiential knowledge of materials gained over time lies at the heart of both design and craft practices. However, empirical studies combining the study of mind and body in relation to design and craft practice is in its ...
Groth, Camilla, Mimmu Rankanen, Rankanen, Mimmu, Camilla Groth, Pirita Seitamaa-Hakkarainen, Maarit Mäkelä, Seitamaa-Hakkarainen, Pirita, Mäkelä, Maarit, Huotilainen, Minna, Marianne Leinikka, Minna Huotilainen, Leinikka, Marianne   +11 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source