FEBS Open Bio, EarlyView.In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley +1 more source
Design of experiments to evaluate pH and temperature parameters with different inoculums in domestic biodigester. [PDF]
HeliyonGómez-Muñoz L +5 more
europepmc +1 more source
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source
Optimization of two-wheeler Bike engine among three different designs using design of experiments. [PDF]
HeliyonDadhich M +6 more
europepmc +1 more source
Evaluation of the effect of metal stents on dose perturbation in the carbon beam irradiation field
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Propose Carbon ion therapy is indicated for cases in which stents have been inserted, such as bile ducts, but the effect of metal stents on carbon ion therapy is unclear. In this study, the dose perturbation of carbon ion therapy caused by metallic bile duct stents was evaluated by dosimetry. Materials and methods Five different types of metal
Yuya Miyasaka +8 more
wiley +1 more source
The Challenge of E-Spinning Sub-Millimeter Tubular Scaffolds-A Design-of-Experiments Study for Fiber Yield Improvement. [PDF]
Polymers (Basel)Sandhoff CA +5 more
europepmc +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose The dual‐layer multileaf collimator (MLC) in Halcyon adds complexities to the dose calculation process owing to the variability of dosimetric characteristics with leaf motion. Recently, an enhanced leaf model (ELM) was developed to refine the MLC model in the Eclipse treatment planning system. This study investigates the performance of
Ryohei Miyasaka +6 more
wiley +1 more source
Optimizing Capacitive Pressure Sensor Geometry: A Design of Experiments Approach with a Computer-Generated Model. [PDF]
Sensors (Basel)Keshyagol K +5 more
europepmc +1 more source
Dose rate correction of a diode array for universal wedge field dosimetric verification
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose To study the performance of MapCHECK 3 (MC3) in measuring universal wedge fields and propose a dose rate correction strategy to improve MC3 measurement accuracy. Materials and methods Universal wedge fields with different wedge angles and field sizes were measured at different depths using MC3.
Linyi Shen +6 more
wiley +1 more source
Implementing the Design of Experiments (DoE) Concept into the Development of Mucoadhesive Tablets Containing Orange Peel Extract as a Potential Concept for the Treatment of Oral Infections. [PDF]
Materials (Basel)Paczkowska-Walendowska M +4 more
europepmc +1 more source