Results 151 to 160 of about 1,673,370 (312)

A Design Pattern for Decentralised Decision Making. [PDF]

open access: yesPLoS One, 2015
Reina A   +4 more
europepmc   +1 more source

The Progress of Creative Pattern Cutting

open access: yes
This paper documents the journey of several research initiatives, which focused upon creative pattern cutting. Instigated by a peer-reviewed, journal paper entitled, ‘Insufficient Allure: The Luxurious Art and Cost of Creative Pattern Cutting’ (Almond ...
Almond, Kevin, Power, Jess
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

The medical science DMZ: a network design pattern for data-intensive medical science. [PDF]

open access: yesJ Am Med Inform Assoc, 2018
Peisert S   +8 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Basic Design

open access: yes, 1986
Vogue Basic Design Pattern #1812 to make a misses' blouse with optional bow or contrast trim at neckline, center front closure, oversize patch pockets at bust, and full long or short sleeves, including illustrations of the finished pieces and information
Vogue Pattern Service
core  

Empowerment through Product Design: Digital textile pattern design for grip development in healthcare [PDF]

open access: yes, 2017
In the meeting between textile pattern design and 3D printing techniques, there is a potential for developing inclusive products for healthcare. There is a great need for this from both patients and healthcare providers. It is further an educational need
Lyche, Wenche, Berg, Arild
core  

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