Results 41 to 50 of about 1,673,370 (312)

Service architecture design for E-Businesses: A pattern-based approach [PDF]

open access: yes, 2008
E-business involves the implementation of business processes over the Web. At a technical level, this imposes an application integration problem. In a wider sense, the integration of software and business levels across organisations becomes a significant
Pahl, Claus, Gacitua-Decar, Veronica
core  

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke   +4 more
wiley   +1 more source

Patterns of Curriculum Design [PDF]

open access: yes, 2003
We present a perspective on the design of a curriculum for a new computer science program at a women’s liberal arts college. The design incorporates lessons learned at the college in its successful implementation of other academic programs, incorporation of best practices in curriculum design at other colleges, results from studies performed on various
Douglas S. Blank, Deepak Kumar 0002
openaire   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook   +6 more
wiley   +1 more source

Computer-Aided Sensor Development Focused on Security Issues

open access: yesSensors, 2016
The paper examines intelligent sensor and sensor system development according to the Common Criteria methodology, which is the basic security assurance methodology for IT products and systems.
Andrzej Bialas
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási   +14 more
wiley   +1 more source

Bad smells in design and design patterns. [PDF]

open access: yesThe Journal of Object Technology, 2009
To give a consistent and more valuable property on models, model-driven processes should be able to reuse the expert knowledge generally expressed in terms of patterns. We focus our work on the design stage and on the systematically use of design patterns.
Bouhours, Cédric   +2 more
openaire   +1 more source

Nature and role of intermediate representation (IR) in the design process [PDF]

open access: yes, 2005
This paper aims to show the key role of the intermediate representations (IR) in the design process and especially in the car design process. For a better understanding of the concept of design, which is by nature conceptual, we propose to study the ...
AOUSSAT, Améziane   +2 more
core  

Using recommendations to help novices to reuse design knowledge [PDF]

open access: yes, 2011
This is the author's accepted manuscript. The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-21530-8_35. Copyright @ Springer 2011.The use of pattern languages is not so straightforward since its users have to identify
Navarro, I, Aedo, I, Malizia, A
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

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