Results 61 to 70 of about 1,250,700 (267)

The Problem of Formulating Design Problems : A Typology of Design Briefs

, 2020
Det är vanligt att ett designteam får ett problem att lösa åt andra. Överlämnandet kallas normalt en ”briefing” -process och dokumentationen av utgångspunkten och vad som ska göras kallas ett ”design brief ”. Det är känt att det sätt vi ramar in och förstår ett problem påverkar vilka vägar vi ser till potentiella lösningar.
openaire   +4 more sources

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Modernization of the "Onyx" photonic annealing system for semiconductor wafers

Технологія та конструювання в електронній апаратурі, 2002
The modernization of the "Onyx" industrial photonic annealing system for semiconductor wafers was carried out to ensure the repeatability and reproducibility of short-duration annealing temperature-time cycles at high heating rates.
H. V. Savytskyi, A. Yu. Bonchyk, I. I. Izhnin, S. H. Kyyak, I. A. Mohyliak, I. P. Trostinskyi   +5 more
doaj  

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Tame, Wicked, and Aporetic Problems in Design

She Ji: The Journal of Design, Economics and Innovation
The article elucidates a type of problem Rittel and Webber did not acknowledge. The underlying assumption about tame and wicked problems is that they are mutually exclusive (any problem can be either wicked or tame but cannot be both or partially wicked ...
Aleksandar Kostić
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

The Problems and Design of a Neck Dummy

Biomimetics
This paper addresses the biomechanical requirements and design of a neck dummy for assessing neck injury risks. The need for an accurate biomechanical representation of the human neck in crash tests is highlighted, emphasizing the importance of replicating the neck’s response to impacts.
Christopher René Torres San Miguel, José Antonio Perez Valdez, Marco Ceccarelli, Matteo Russo   +3 more
openaire   +4 more sources

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

SIMULATION RESULTS OF SPECKLE SUPPRESSION IN RADAR WITH SYNTHETIC APERTURE

Научный вестник МГТУ ГА, 2019
The disadvantage of (RLI) radar images obtained with a single-channel radar station is the presence of speckle that leads to intensity flashes increasing the number of false alarms when detecting point targets.
R. N. Akinshin, V. L. Rumyantzev, A. V. Peteshov   +2 more
doaj   +1 more source