Integrating behavioural science and design thinking to develop a water treatment innovation in Malawi healthcare: a case study of the intervention design process. [PDF]
Glob Health ActionPittalis C +6 more
europepmc +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
The design process : presentation transcript
, 2010 This is a presentation about the Design Process HNC In Engineering – Design for manufacture Edexcel HN Unit: Engineering Science (NQF L4). The presentation looks at the design process as applied to practical engineering situations.
Leicester College Technology and Engineering Centre
core
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Artificial Intelligence in Metal Additive Manufacturing: Applications in Design, Process Modeling, Monitoring, and Quality Optimization. [PDF]
Materials (Basel)Sustacha J +3 more
europepmc +1 more source
Analysis of Design Process Dynamics.
, 2004 To enable the development of automated support for design, a challenge is to model and analyse dynamics of design processes in a formal manner. This paper contributes a declarative, logical approach for specification of dynamic properties of design processes, supported by a formal temporal language.
Bosse, T., Jonker, C.M., Treur, J.
openaire +4 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Facilitating food security systems change in regional Australia through a strengths-based, co-design process. [PDF]
Health Promot IntChiera I +4 more
europepmc +1 more source
Integrating sustainability in the design process of urban service robots. [PDF]
Front Robot AI, 2023 van der Schoor MJ, Göhlich D.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source