Results 171 to 180 of about 4,145,489 (318)

Reflections on the Inclusive Co-Design Process of a Virtual Assistant for Individuals With Complex Care Needs: Mixed Methods Study. [PDF]

JMIR Hum Factors
van Calis JFE, Bevelander KE, van der Cruijsen AWC, Naaldenberg J, Leusink GL.   +4 more
europepmc   +1 more source

Analysis of Design Process Dynamics.

, 2004
To enable the development of automated support for design, a challenge is to model and analyse dynamics of design processes in a formal manner. This paper contributes a declarative, logical approach for specification of dynamic properties of design processes, supported by a formal temporal language.
Bosse, T., Jonker, C.M., Treur, J.
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Integrated Design Process for Prefabricated Façade Modules with Embedded Distributed Service Systems

, 2011
The awareness of the environmental impact of buildings concerning their CO2 emissions, their energy and resource consumption has raised the challenges on building design, construction and operation.
A. Schlueter
core  

Adopting an Integrative and Co-Design Process to Contextualize Management Capacity Building in Hospitals. [PDF]

J Healthc Leadersh
Liang Z, Zhang H.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

ROOM to Grow, a Mobile Well-Being Intervention for University Students: Overview of the Design Process and Outcomes. [PDF]

JMIR Form Res
Laure T, Villegas Meija C, Remmerswaal D, Dulloo D, Van der Hallen R, Mayer B, Littel M, Dierckx B, Legerstee JS, Engels RCME, Boffo M.   +10 more
europepmc   +1 more source

Development and evaluation of food preservation lessons for gardeners: application of the DESIGN process. [PDF]

Public Health Nutr, 2023
Beavers AW, Kennedy AO, Blake JP, Comstock SS.   +3 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Multicriteria process development and design

, 2006
Structural and societal changes in process industry have lead to new requirements in process development, design and project management. The growing importance of health, safety and environmental aspects has increased the number of criteria considered in
Cziner, Krisztina
core