Results 211 to 220 of about 4,145,489 (318)

Implementing Cultural Safety in Research Methodology: The Co-Design Process of a Brief Therapeutic Intervention for Aboriginal and Torres Strait Islander Young People Who Engage in Self-Harm and/or Suicidal Behaviours. [PDF]

Aust J Rural Health
D'Mello C, Milroy H, Papageorgiou A, Coleman M, Dudgeon P, Anderson P, Batty D, Lin A.   +7 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

AI-Based Hospital Design Process through Neuro-Symbolic Strategies. [PDF]

Arch Bone Jt Surg
Fattahi Maassoum AS, Farkisch H, Taji M.
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The Design Process of a Digital Patient Decision Tool to Increase Sexually Transmitted Infection Testing in the Emergency Department. [PDF]

Sex Transm Dis
Chernick LS, Adler T, De Souza JN, Franqui CN, Tchoungui LP, Caselli A, Tyndell A, Castilho R, Probst MA, Castor D, Zucker J.   +10 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Developing a Weight-Neutral Health Intervention in Denmark: Protocol for a Co-Design Process. [PDF]

JMIR Public Health Surveill
Meyer L, Køster-Rasmussen R, Christiansen AL, Heitmann BL, Vesterlund GK, Larsen SC, Specht IO, Thorsteinsdottir F, Steinbo EKF, Appel CL, Sigurdardottir GA, Reventlow S, Waldorff FB, Sandholdt CT.   +13 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A co-design process to develop personalized mobility programming for individuals with mobility impairments. [PDF]

Front Rehabil Sci
Cimino SR, Crozier O, Lizotte D, Shabbir A, Stoikos J, Wolfe DL.   +5 more
europepmc   +1 more source

Designing Process Guidance Systems

Journal of the Association for Information Systems, 2019
Morana, Stefan, Kroenung, Julia, Maedche, Alexander, Schacht, Silvia   +3 more
openaire   +4 more sources