Results 231 to 240 of about 21,433,054 (296)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Product innovation design process combined Kano and TRIZ with AD: Case study. [PDF]

PLoS One
Rong H, Liu W, Li J, Zhou Z.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Codevelopment of an mHealth App With Health Care Providers, Digital Health Experts, Community Partners, and Families for Childhood Obesity Management: Protocol for a Co-Design Process. [PDF]

JMIR Res Protoc
Toh SH, Davis C, Bte Khaider K, Ong ZQ, Lim EJK, Chew CSE.   +5 more
europepmc   +1 more source

Dispersion Influence of Electroacoustic Transducer Parameters in the Design Process of Miniature Loudspeaker Arrays and Omnidirectional Sound Sources. [PDF]

Sensors (Basel)
Chojnacki B.
europepmc   +1 more source

Fanau Manuia programme: key findings from a co-design process using a Pacific family-based approach to address pre-diabetes risk among Pacific children, New Zealand. [PDF]

BMJ Public Health
Tupai-Firestone R, Pulu T, Lerwill N, Pulu V, Latu L, Aitaoto N, Gokhale P, Borman B, Corbin M, Firestone J, Kingi TK, Krebs J, Matheson A, Tapu-Ta'ala S, Henry A, Samoa R, Read D, Fuge K.   +17 more
europepmc   +1 more source

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Designing the process design process

Computers & Chemical Engineering, 1997
Abstract We suggest that designing design processes is an ill-posed problem which must be tackled with great care and in an evolutionary fashion. We argue it is an important activity, however, as companies today use a small percentage of the intellectual capital they own when designing, suggesting there is room for significant improvement. We discuss
Arthur W. Westerberg, Eswaran Subrahmainan, Yoram Reich, Suresh Konda   +3 more
openaire   +2 more sources

The Process of Inclusive Design

2016 IEEE 16th International Conference on Advanced Learning Technologies (ICALT), 2016
Re-thinking the process of designing inclusive systems may help to identify the potential for re-use and interoperability of developed systems. Based on existing models of system engineering and project management, a process model for inclusive design as well as consequences for its practical application are presented.
Ulrike Lucke, Thais Castro
openaire   +1 more source