Results 251 to 260 of about 4,145,489 (318)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Dispersion Influence of Electroacoustic Transducer Parameters in the Design Process of Miniature Loudspeaker Arrays and Omnidirectional Sound Sources. [PDF]

Sensors (Basel)
Chojnacki B.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Fanau Manuia programme: key findings from a co-design process using a Pacific family-based approach to address pre-diabetes risk among Pacific children, New Zealand. [PDF]

BMJ Public Health
Tupai-Firestone R, Pulu T, Lerwill N, Pulu V, Latu L, Aitaoto N, Gokhale P, Borman B, Corbin M, Firestone J, Kingi TK, Krebs J, Matheson A, Tapu-Ta'ala S, Henry A, Samoa R, Read D, Fuge K.   +17 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Numerical and Experimental Analyses of Developed Friction Stir Spot Welding (DFSSW) Based on Systematic Design Process Approach. [PDF]

ScientificWorldJournal
Abd Al-Sahb WS, Hussein SG, Mohammed MN, Abdullah OI.   +3 more
europepmc   +1 more source

First iteration of a User-Centered Design process to develop an in-bed leg press. [PDF]

Technol Health Care
Cerrito A, Fang J, Schertenleib SJG, Hunt KJ, Schmitt KU.   +4 more
europepmc   +1 more source

Translating a motivational interviewing intervention for childhood cancer survivors into an eHealth tool: A user-centered design process. [PDF]

Transl Behav Med
Ruiz S, Ackermann N, Maki J, Carcone AI, Hudson MM, Ehrhardt MJ, Cloakey D, DuChateau D, Griffith SA, Johnson A, Phillips A, Waters EA.   +11 more
europepmc   +1 more source