Results 91 to 100 of about 9,618,868 (311)

Trade and biodiversity conservation in Africa: Complementary roles of environmental provisions in preferential trade agreements and property rights

Cleaner and Responsible Consumption
Biodiversity loss has become a major environmental concern in regions experiencing rapid trade integration, yet the roles of trade agreements and property rights in shaping biodiversity outcomes remains insufficiently understood.
Michael Tutu Boadu, Camara K. Obeng
doaj   +1 more source

Assessment of fib Bulletin 90 Design Provisions for Intermediate Crack Debonding in Flexural Concrete Elements Strengthened with Externally Bonded FRP. [PDF]

Polymers (Basel), 2023
Codina A, Barris C, Jahani Y, Baena M, Torres L.   +4 more
europepmc   +1 more source

Overcoming Design Fixation in Idea Generation [PDF]

, 2018
Ideally, designers move past existing ideas to create novel designs. But designers often experience “fixation,” where new ideas are similar to existing designs.
Seifert, Colleen, Daly, Shanna, Leahy, Keelin, Shanna Daly, McKilligan, Seda, Seda McKilligan, Colleen Seifert, Keelin Leahy   +7 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Interpretations of design thinking across a large organization

, 2019
Design thinking has a prominent role as established corporations ramp up innovation efforts focusing on user needs. Current literature provides a plethora of definitions for design thinking with variations in tools, methods and cultures.
Björklund, Tua, van der Marel, Floris, Kosmala, Martyna   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Strut-and-Tie Method for GFRP-RC Deep Members

International Journal of Concrete Structures and Materials
The current code provisions in ACI 440.11 are based on the flexural theory that applies to slender members and may not represent the actual structural behavior when the shear span-to-reinforcement depth ratio is less than 2.5 (i.e., deep members).
Zahid Hussain, Antonio Nanni
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source