Results 121 to 130 of about 9,618,868 (311)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Enhancement of seismic resistance of buildings [PDF]

open access: yesUrbanism. Arhitectura. Constructii, 2014
The objectives of the paper are both seismic instrumentation for damage assessment and enhancing of seismic resistance of buildings. In according with seismic design codes in force the buildings are designed to resist at seismic actions.
Claudiu-Sorin Dragomir   +2 more
doaj  

Labor Provisions in Trade Agreements (LABPTA): Introducing a New Dataset

open access: yes, 2018
Global labor policy through trade has begun to receive growing attention with the inclusion of labor provisions in preferential trade agreements (PTAs).
Sari, Dora, Räss, Damian
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigation on the Buckling Behavior of Normal Steel CHS Beam–Columns: A Revised Design Approach with Reliability Analysis

open access: yesBuildings
This paper focuses on the buckling behavior of circular hollow section (CHS) beam–columns. The literature review highlights the need for further investigations to improve the accuracy of structural performance predictions and optimize the design ...
Musab Rabi
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Use of seismic design provisions assessed

open access: yesEos, Transactions American Geophysical Union, 1978
New buildings may soon incorporate seismic design criteria developed by the Center for Building Technology of the National Bureau of Standards (NBS). The design criteria reflect the current state of the art in earthquake engineering in a form adaptable for implementation by standards organizations, model code groups, federal agencies, and other ...
openaire   +1 more source

The Case for Space: Reviving Cosmic Conscience, Provisional Reasearch Journal, A Provisions Library Journal, Volume 1, Issue 4

open access: yes, 1905
Provisional Research is a digital journal publishing the findings of Provisions research projects and residencies. Provisional Research seeks to provide free and accessible public information on creative projects, sharing strategies and practices for ...
Sherman, Stephanie, Russell, Don
core   +1 more source

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