Results 1 to 10 of about 22,992,422 (339)

Scale-Agnostic Models Based on Dimensionless Quality by Design as Pharmaceutical Development Accelerator

open access: yesPharmaceuticals
This comprehensive review of the synergistic use of Quality by Design (QbD) and the Pi–Buckingham theorem explores an innovative approach to enhancing product development and process optimization within the pharmaceutical industry.
Miquel Romero-Obon   +6 more
doaj   +1 more source

Application of the concept of design space in method development for the determination of contaminants in soil [PDF]

open access: yesProceedings of the Estonian Academy of Sciences
The analysis of polycyclic aromatic hydrocarbons and polychlorinated biphenyls is an important topic in environmental analysis, and several analysis procedures have already been proposed.
Jelena Jurjeva, Mihkel Koel
doaj   +1 more source

Formulation Considerations for Autologous T Cell Drug Products

open access: yesPharmaceutics, 2021
Genetically modified autologous T cells have become an established immunotherapy in the fight against cancer. The manufacture of chimeric antigen receptor (CAR) and αβ-T cell receptor (TCR) transduced T cells poses unique challenges, including the ...
Christopher F. van der Walle   +3 more
doaj   +1 more source

Quantifying "Cliffs" in Design Space

open access: yes, 2014
This paper studies the regions of parameter space of engineering design in which performance is sensitive to design parameters. Some of these parameters (for example, the dimensions and compositions of components) constitute the design, but others are ...
Katz, J. I.
core   +1 more source

Development of a Quantitative Chromatographic Fingerprint Analysis Method for Sugar Components of Xiaochaihu Capsules Based on Quality by Design Concept

open access: yesSeparations, 2022
Background: Xiaochaihu capsule is composed of seven traditional Chinese medicines. The pharmacopoeia only focuses on the quantitative detection of baicalin, which cannot fully reflect the quality of the preparation. Some medium polar components were used
Jing Lan   +7 more
doaj   +1 more source

Design spaces: The explicit representation of spaces of alternatives [PDF]

open access: yesArtificial Intelligence for Engineering Design, Analysis and Manufacturing, 2006
This Special Issue is in an exceptional format. Starting with an invited Keynote by Rob Woodbury and Andrew Burrow, the rest of the issue is taken up by invited papers that are responses to Woodbury and Burrow's paper, written by selected authorities on design. A final short section is devoted to Woodbury and Burrow's reactions to the responses.
openaire   +2 more sources

DESIGN CONCEPT - WARM INTERIOR SPACE [PDF]

open access: yes, 2012
Current housing development increased along with the human need for shelter. Nowadays residence is not only used by the owner directly, but also has shifted as a function of investment or leased to other parties.
Nyoman, Dewi Pebryani, S.T., M.A
core  

Quality by Design-Guided Systematic Development and Optimization of Mucoadhesive Buccal Films

open access: yesPharmaceutics, 2023
Mucoadhesive buccal films have found increased popularity in pharmaceutical drug delivery due to the several advantages that they possess. The present study strives to develop and optimize chitosan-based mucoadhesive buccal films by relying on quality-by-
Alharith A. A. Hassan   +4 more
doaj   +1 more source

Designing spaces for every listener

open access: yesUniversal Access in the Information Society, 2009
Inclusive design aims at objects and environments that are accessible, usable and comfortable for all people throughout their entire lifespan. In architecture, this aim is usually associated with physical accessibility. Yet acoustic qualities may considerably impact usability and comfort as well, especially in spaces for listening.
Ann Heylighen   +2 more
openaire   +1 more source

Application of dendrogram-directed design space exploration to bi-objective permutation flow-shop scheduling problem

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2022
In this study, we propose a method for structurally understanding the differences and similarities among the alternatives of a bi-objective permutation scheduling problem.
Masato TOI   +3 more
doaj   +1 more source

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