Results 41 to 50 of about 13,714,700 (299)

FLARE: A design environment for FLASH-based space applications [PDF]

open access: yes, 2009
Designing a mass-memory device (i.e., a solid-state recorder) is one of the typical issues of mission-critical space system applications. Flash-memories could be used for this goal: a huge number of parameters and trade-offs need to be explored.
Stefano Di Carlo   +8 more
core   +1 more source

Scale-Agnostic Models Based on Dimensionless Quality by Design as Pharmaceutical Development Accelerator

open access: yesPharmaceuticals
This comprehensive review of the synergistic use of Quality by Design (QbD) and the Pi–Buckingham theorem explores an innovative approach to enhancing product development and process optimization within the pharmaceutical industry.
Miquel Romero-Obon   +6 more
doaj   +1 more source

An atlas of gene regulatory networks reveals multiple three‐gene mechanisms for interpreting morphogen gradients

open access: yesMolecular Systems Biology, 2010
The interpretation of morphogen gradients is a pivotal concept in developmental biology, and several mechanisms have been proposed to explain how gene regulatory networks (GRNs) achieve concentration‐dependent responses.
James Cotterell, James Sharpe
doaj   +1 more source

Application of the concept of design space in method development for the determination of contaminants in soil [PDF]

open access: yesProceedings of the Estonian Academy of Sciences
The analysis of polycyclic aromatic hydrocarbons and polychlorinated biphenyls is an important topic in environmental analysis, and several analysis procedures have already been proposed.
Jelena Jurjeva, Mihkel Koel
doaj   +1 more source

Evaluating the suitability of underground space development based on social and economic factors

open access: yesUrban, Planning and Transport Research, 2023
Ma’anshan City, located in the Yangtze River Delta region, is a demonstration city for handling the industrial transfer of the Nanjing, Hefei, and Wanjiang Metropolitan Areas in China.
Yilan Yan, Minghe Sun, Yunpeng Li
doaj   +1 more source

Design spaces: The explicit representation of spaces of alternatives [PDF]

open access: yesArtificial Intelligence for Engineering Design, Analysis and Manufacturing, 2006
This Special Issue is in an exceptional format. Starting with an invited Keynote by Rob Woodbury and Andrew Burrow, the rest of the issue is taken up by invited papers that are responses to Woodbury and Burrow's paper, written by selected authorities on design. A final short section is devoted to Woodbury and Burrow's reactions to the responses.
openaire   +3 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Uncovering terra incognita in the AHD design space: A review of affective haptic devices

open access: yesFrontiers in Computer Science, 2022
Affective haptic devices (AHDs) have been developed with the aim of communicating touch acts, symbolic messages, emotions, and/or providing a sense of social awareness.
Sima Ipakchian Askari   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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