Results 61 to 70 of about 13,714,700 (299)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Frontiers in Computer ScienceAlthough gesture-based explanations for robotic behavior seem promising for enhancing the transparency of robotic systems, careful design is crucial to their success.
Ilka Hein +3 more
doaj +1 more source
Design Space by Design of Experiments
Journal of Pharmaceutical Research International, 2021 The quality of methods and products are usually influenced by several input factors. Research has recently focused on understanding the effects of multidimensional and interconnected input factors on the results of pharmaceutical products and analytical methods using Design of Experiment (DoE).
Ashwin Kuchekar +2 more
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Quality by Design-Guided Systematic Development and Optimization of Mucoadhesive Buccal Films
Pharmaceutics, 2023 Mucoadhesive buccal films have found increased popularity in pharmaceutical drug delivery due to the several advantages that they possess. The present study strives to develop and optimize chitosan-based mucoadhesive buccal films by relying on quality-by-
Alharith A. A. Hassan +4 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
IEEE AccessTechnology-mediated audience participation (TMAP) offers a wide variety of ways to enhance the involvement of spectators during a music performance. Technological change has created rich new opportunities for such interactive performance experiences ...
Oliver Hodl, Luca Turchet
doaj +1 more source
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2022 In this study, we propose a method for structurally understanding the differences and similarities among the alternatives of a bi-objective permutation scheduling problem.
Masato TOI +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source