Results 91 to 100 of about 22,992,422 (339)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Investigation on the Design Space of the Primary Drying Stage of Spray-Freeze-Drying Technology

Energies
Spray-freeze-drying technology has gained considerable interest worldwide. However, the high energy consumption and lengthy process duration have hindered its further development.
Shen Weihua, Liu Bo, Luo Chun, Sun Dongze, Yin Wei   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A design space for event-centric displays in public libraries

Frontiers in Computer Science
We present a design space for displays in public libraries; more specifically public displays related to events taking place in the library. The design space is developed from the perspective of the librarians and is intended to support libraries in ...
Alix Ducros, Aurélien Tabard, Aurélien Tabard, Peter Dalsgaard, Raphaelle Bats, Eva Eriksson   +5 more
doaj   +1 more source

Realization of SRRC filter and multi-rate conversion based on FPGA

Dianzi Jishu Yingyong, 2018
In order to eliminate the inter symbol interference(ISI) in the communication system and improve the band utilization, the square root-raised cosine filter is often used to realize the base-band shaping filter of the baseband signal.
Yang Yang, Yan Zheng, Liu Minwei, Dong Jicheng   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Guaranteed passive parameterized macromodeling by using Sylvester state-space realizations [PDF]

, 2013
A novel state-space realization for parameterized macromodeling is proposed in this paper. A judicious choice of the state-space realization is required in order to account for the assumed smoothness of the state-space matrices with respect to the design
Dhaene, Tom, Ferranti, Francesco, Knockaert, Luc, Samuel, Elizabeth Rita   +3 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Design of the Spitzer Space Telescope Heritage Archive [PDF]

, 2009
It is predicted that Spitzer Space Telescope’s cryogen will run out in April 2009, and the final reprocessing for the cryogenic mission is scheduled to end in April 2011, at which time the Spitzer archive will be transferred to the NASA/IPAC Infrared ...
Alexov, A., Berriman, G. B., Capak, P., Good, J., Groom, S., Handley, T., Kirkpatrick, J. D., Lacy, M., Laher, Russ R., Laine, S., Legassie, M., Levine, Deborah, Ly, L., Roby, T., Wu, X.   +14 more
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source