Results 111 to 120 of about 22,992,422 (339)

The optimal design of standard gearsets [PDF]

open access: yes, 1983
A design procedure for sizing standard involute spur gearsets is presented. The procedure is applied to find the optimal design for two examples - an external gear mesh with a ratio of 5:1 and an internal gear mesh with a ratio of 5:1.
Coy, J. J., Savage, M., Townsend, D. P.
core   +1 more source

Exploring the Design Space of Immersive Urban Analytics

open access: yes, 2017
Recent years have witnessed the rapid development and wide adoption of immersive head-mounted devices, such as HTC VIVE, Oculus Rift, and Microsoft HoloLens.
Chen, Wei   +7 more
core   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Computer-Aided Design of Digital Compensators for DC/DC Power Converters

open access: yesEnergies, 2018
Digital control of high-frequency power converters has been used extensively in recent years, providing flexibility, enhancing integration, and allowing for smart control strategies. The core of standard digital control is the discrete linear compensator,
Pablo Zumel   +4 more
doaj   +1 more source

Enhanced function-means modeling supporting design space exploration

open access: yesArtificial intelligence for engineering design, analysis and manufacturing, 2019
One problem in incremental product development is that geometric models are limited in their ability to explore radical alternative design variants. In this publication, a function modeling approach is suggested to increase the amount and variety of ...
Jakob R. Müller   +6 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Design concepts for bioreactors in space [PDF]

open access: yes
Microbial food sources are becoming viable and more efficient alternatives to conventional food sources, especially in the context of closed ecological life support systems (CELSS) in space habitats. Two bioreactor design concepts presented represent two
Beard, B.   +4 more
core   +4 more sources

Parameter Optimization Considering the Variations Both from Materials and Process: A Case Study of Scutellaria baicalensis Extract

open access: yesSeparations
The Quality by Design (QbD) concept has been widely applied to the optimization of traditional Chinese medicine production processes recently. This work focused on optimizing the critical purification process of Scutellaria baicalensis extract used in ...
Xuecan Zhang   +3 more
doaj   +1 more source

Large space structure damping design [PDF]

open access: yes
Several FORTRAN subroutines and programs were developed which compute complex eigenvalues of a damped system using different approaches, and which rescale mode shapes to unit generalized mass and make rigid bodies orthogonal to each other.
Haviland, J. K., Pilkey, W. D.
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

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