Results 241 to 250 of about 5,060,080 (299)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu   +10 more
wiley   +1 more source

Traumatic Microhemorrhages Are Not Synonymous With Axonal Injury

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diffuse axonal injury (DAI) is caused by acceleration‐deceleration forces during trauma that shear white matter tracts. Susceptibility‐weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical prognostication.
Karinn Sytsma   +9 more
wiley   +1 more source

Meningovascular Inflammation in Cerebral Amyloid Angiopathy‐Related Cortical Superficial Siderosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post‐contrast vessel wall MRI (VWI) and CSF analysis.
Philipp Arndt   +8 more
wiley   +1 more source

Space-filling experimental designs for constrained design spaces

Engineering Optimization, 2018
Conventional space-filling experimental design provides uniform coverage of a hypercube design space. When constraints are imposed, the results may contain many infeasible points.
Zeping Wu   +5 more
openaire   +1 more source

Lyophilization Process Design Space

Journal of Pharmaceutical Sciences, 2013
The application of key elements of quality by design (QbD), such as risk assessment, process analytical technology, and design space, is discussed widely as it relates to freeze-drying process design and development. However, this commentary focuses on constructing the Design and Control Space, particularly for the primary drying step of the freeze ...
Sajal Manubhai, Patel, Michael J, Pikal
openaire   +2 more sources

The design space layer

Proceedings of the conference on Design, automation and test in Europe, 1999
A novel library layer, called the "design space layer," is proposed, aimed at supporting both IP-based and traditional "in-house" design methodologies, during early design space exploration. Strategies for effectively pruning the large design spaces characteristic of system-on-a-chip designs, and for transparently retrieving information on cores ...
H.P. Peixoto   +3 more
openaire   +1 more source

Design space optimization using design space adjustment and refinement

Structural and Multidisciplinary Optimization, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Jang, IG Jang, In Gwun   +1 more
openaire   +2 more sources

Trading design spaces

CHI '04 Extended Abstracts on Human Factors in Computing Systems, 2004
Physical design environments are places that support people engaged in the spatial, physical, tangible act of creation. It is now possible to augment workspaces with an amazing array of technologies to assist users in their creative endeavors. However, the integration of computing technologies into physical environments involves a new set of tools ...
Wendy Ju   +6 more
openaire   +1 more source

Space Station Design

SAE Technical Paper Series, 1970
<div class="htmlview paragraph">This paper is a brief review of the background of space station design effort from the time manned space flight was initiated to the present. The existing technology base for implementation of an ambitious earth-orbital operations program is briefly commented upon. Current space station designs are discussed in the
Rene A. Berglund, Jack C. Heberlig
openaire   +1 more source

Whither design space?

Artificial Intelligence for Engineering Design, Analysis and Manufacturing, 2006
Design space exploration is a long-standing focus in computational design research. Its three main threads are accounts of designer action, development of strategies for amplification of designer action in exploration, and discovery of computational structures to support exploration. Chief among such structures is the design space, which is the network
ROBERT F. WOODBURY, ANDREW L. BURROW
openaire   +1 more source

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