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Quality by Design for the Nanoformulation of Cosmeceuticals [PDF]
PharmaceuticsCosmeceuticals are cosmetic formulations that are intended to alleviate skin conditions that affect its appearance and functionality. They are not considered medications but contain molecules that exert biological action on the skin beyond traditional ...
Gerardo Leyva-Gómez +6 more
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Quality by Design: Concepts for ANDAs [PDF]
AAPS Journal, 2008 Quality by design is an essential part of the modern approach to pharmaceutical quality. There is much confusion among pharmaceutical scientists in generic drug industry about the appropriate element and terminology of quality by design. This paper discusses quality by design for generic drugs and presents a summary of the key terminology. The elements
Robert Lionberger +2 more
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Frontiers in Plant Science, 2022 Lilium is a popular cut flower that is highly favored by consumers due to its snowy white color and strong fragrance, which originates from the release of monoterpenes.
Yun-Yao Yang +10 more
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Quality by design approach with design of experiment for sample preparation techniques
Advances in Sample Preparation, 2023 The quality by design (QbD) based approach has begun to be embedded in various method development. Studies show that with the design of experiment tool, the analysis process has become more efficient, faster, and easier.
Saniye Özcan +2 more
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Frontiers in Bioengineering and Biotechnology, 2021 RNA interference (RNAi) has an unprecedented potential as a therapeutic strategy for reversibly silencing the expression of any gene. Therapeutic delivery of the RNAi mediator, i.e., small interfering RNA (siRNA), can be used to address diseases ...
Abhijeet Lokras +5 more
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Pharmaceutics, 2021 Low aqueous solubility and poor oral bioavailability are limiting factors in the oral delivery of voxelotor, an antisickling agent. To overcome these limitations, a voxelotor self-nanoemulsifying drug delivery system was developed.
Aristote B. Buya +6 more
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Molecules, 2022 Carvedilol (CAR), a racemic lipophilic aryloxy propanolamine, acts as a selective α1-adrenoreceptor antagonist and a nonselective β-adrenoreceptor antagonist. CAR metabolism mainly produces three active metabolites: desmethyl carvedilol (DMC), 4′-hydroxy
Liza Samir +3 more
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To improve quality, leverage design [PDF]
BMJ Quality & Safety, 2021 The year was 1987, and a bold experiment was under way—the US-based National Demonstration Project in Quality Improvement in Health Care (NDP). This effort brought together 21 companies recognised for excellence in quality manufacturing with 21 healthcare organisations to test whether revolutionary practices from quality improvement (QI) could be ...
Byron Crowe +13 more
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Pharmaceutics, 2022 In the pharmaceutical industry, the systematic optimization of process variables using a quality-by-design (QbD) approach is highly precise, economic and ensures product quality. The current research presents the implementation of a design-of-experiment (
Mohamed H. Fayed +3 more
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Pharmaceutics, 2020 The particle size (PS) and encapsulation efficiency (EE%) of drug-loaded nanoparticles (NPs) may inhibit their cellular uptake and lead to possible leakage of the drug into the systemic circulation at the tumor site.
Mohamed Haider +4 more
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