Results 21 to 30 of about 2,590,147 (263)

QbD approach to HPLC method development and validation of ceftriaxone sodium

Future Journal of Pharmaceutical Sciences, 2021
Background Quality by design (QbD) refers to the achievement of certain predictable quality with desired and predetermined specifications. A quality-by-design approach to method development can potentially lead to a more robust/rugged method due to ...
Krunal Y. Patel, Zarna R. Dedania, Ronak R. Dedania, Unnati Patel   +3 more
doaj   +1 more source

Understanding barriers and benefits to adopting elephant coexistence practices in oil palm plantation landscapes in Lower Kinabatangan, Sabah

Frontiers in Conservation Science, 2022
Oil palm managers are one of the key stakeholders who could help strengthen efforts to protect elephants in the landscape. We used a Theory of Change (ToC) approach to hypothesize potential barriers and benefits to managers adopting best practise.
Nurzhafarina Othman, Nurzhafarina Othman, Muhammad Al-Shafieq Mustapah, Aida Ghani Quilter, Amielle DeWan   +4 more
doaj   +1 more source

Development and study of the stability of comenic acid solutions

Разработка и регистрация лекарственных средств, 2021
Introduction. The article presents the development of solutions based on the comenic acid substance. The criteria of the studied compositions that affect their stability during storage are evaluated within the framework of the Quality-by-Design concept ...
T. A. Bitkina, A. V. Basevich
doaj   +1 more source

Quality by Design approach for nanosystem based topical drug delivery

German Journal of Pharmaceuticals and Biomaterials, 2023
The skin is increasingly being acknowledged as a chief drug administration route. Its natural barrier stratum corneum (SC) usually obstructs this route's effectiveness; hence, different strategies have been investigated to improve percutaneous drug ...
Veeranti Vipanchi, Maimuna Fatima, Prasanthi Domaraju   +2 more
doaj   +1 more source

Tablets Development Based on Clover Meadow Grass Phytosubstance Using Design of the Experiment Method and QdD Tools

Разработка и регистрация лекарственных средств, 2020
Introduction. Quality, along with efficacy and safety, are the key characteristics of a drug. Therefore, it is important in frame of pharmaceutical development to lay the foundation for obtaining a quality product and achieving the desired product ...
A. N. Golubev, Th. I. Nguen, V. V. Sorokin, I. E. Kauhova   +3 more
doaj   +1 more source

A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion Formulation Development

Pharmaceutics, 2022
Several literature publications have described the potential application of active pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD) formulations via the hot ...
Samuel O. Kyeremateng, Kristin Voges, Stefanie Dohrn, Ekaterina Sobich, Ute Lander, Stefan Weber, David Gessner, Rachel C. Evans, Matthias Degenhardt   +8 more
doaj   +1 more source

"QUALITY BY DESIGN" IN LIPOSOMAL DRUGS CREATION [PDF]

Biotechnologia Acta, 2020
Nanobiotechnological preparations creation is one of the promising areas of modern pharmacy, since it allows creating products of a qualitatively new level. The procedure development, based on an understanding of the product characteristics and the technological process, confirmed by reliable scientific data.
Yu. М. Krasnopolsky, D. М. Pylypenko
openaire   +3 more sources

Development of an HPLC-MS/MS Method for Chiral Separation and Quantitation of (R)- and (S)-Salbutamol and Their Sulfoconjugated Metabolites in Urine to Investigate Stereoselective Sulfonation

Molecules, 2023
The aim of this study was to develop and optimize a chiral HPLC-MS/MS method for quantitative analysis of (R)-/(S)-salbutamol and (R)-/(S)-salbutamol-4′-O-sulfate in human urine to allow for bioanalytical quantitation of the targeted analytes and ...
Lukas Corbinian Harps, Annika Lisa Jendretzki, Clemens Alexander Wolf, Ulrich Girreser, Gerhard Wolber, Maria Kristina Parr   +5 more
doaj   +1 more source

Reconciling Quality by Design and Transdermal Product Development

Pharmaceutics, 2020
Since my first exposure to the acronym ‘QbD’ more than ten years ago, I have been trying to understand exactly what QbD is and how I might incorporate its teachings into my twenty-odd years of experience developing transdermal systems. I feel
Kenneth Miller
doaj   +1 more source

Rational Development of a Carrier-Free Dry Powder Inhalation Formulation for Respiratory Viral Infections via Quality by Design: A Drug-Drug Cocrystal of Favipiravir and Theophylline

Pharmaceutics, 2022
Formulating pharmaceutical cocrystals as inhalable dosage forms represents a unique niche in effective management of respiratory infections. Favipiravir, a broad-spectrum antiviral drug with potential pharmacological activity against SARS-CoV-2, exhibits
Si Nga Wong, Jingwen Weng, Ignatius Ip, Ruipeng Chen, Richard Lakerveld, Richard Telford, Nicholas Blagden, Ian J. Scowen, Shing Fung Chow   +8 more
doaj   +1 more source