Results 61 to 70 of about 166,983 (266)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Supervised Design-Space Exploration
, 2015 Low-cost Very Large Scale Integration (VLSI) electronics have revolutionized daily life and expanded the role of computation in science and engineering. Meanwhile, process-technology scaling has changed VLSI design to an exploration process that strives for the optimal balance among multiple objectives, such as power, performance, and area, i.e.
openaire +2 more sources
Exploration of Axial Fan Design Space with Data-Driven Approach
International Journal of Turbomachinery, Propulsion and Power, 2019 Since the 1960s, turbomachinery design has mainly been based on similarity theory and empirical correlations derived from experimental data and manufacturing experience. Over the years, this knowledge was consolidated and summarized by parameters such as
Gino Angelini +3 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Design Space Exploration of DICE
Proceedings of the 17th International Conference on Availability, Reliability and Security, 2022 Dominik Lorych, Lukas Jäger
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Applied SciencesThe aerodynamic performance of racing motorcycles plays a crucial role in improving speed, stability, and rider control under dynamic conditions. While most existing studies focus on front-mounted winglets and fairing extensions, the aerodynamic role of ...
Massimiliano Chillemi +4 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source