Results 181 to 190 of about 10,346,027 (303)

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Assessing multidimensional student engagement in studio-based design learning: a traceable multimodal framework for teacher-led inquiry. [PDF]

Front Psychol
Meng Y, Wang Z, Ruan B.
europepmc   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Mechanochemical Engineered Sulfur Copolymers Onto Group 13 and Related Fillers Through Lewis Acid‐Base Pairing

Advanced Science, EarlyView.
Green mechanochemical copolymerization was developed for universal interfacial modification of Group 13 and related fillers. By leveraging Lewis acid–base coordination to anchor sulfur‐containing polymers—validated via multiscale characterization and DFT—this versatile method boosts performance across liquid fuels, thermal‐shielding materials, and ...
Chen Wang, Xiaoyang Shao, Zixuan Lei, Ruoqing Zhao, Xiaozhong Bao, Shuiping Zhou, Wen Ao, Zhenhua Wang   +7 more
wiley   +1 more source

Is hands-on learning still necessary in the age of AI? A thematic review. [PDF]

Front Psychol
Yu J, Liu L, Zhu Q.
europepmc   +1 more source

Loss‐Engineered Terahertz Pixelated Metasensors for Enhanced Molecular Vibrational Fingerprint Sensing

Advanced Science, EarlyView.
This work presents a THz pixelated metasensor that employs loss optimization and spectral overlap for enhanced molecular vibrational fingerprint sensing. The flexible loss rate tuning through the out‐of‐plane dimension allows the device to operate in the optimal fingerprint enhancement condition.
Chenglin Yang, Yuqing Cui, Donghai Han, Yushan Hou, Zhonglei Shen, Andreas Tittl, Liuyang Zhang, Ruqiang Yan, Xuefeng Chen   +8 more
wiley   +1 more source

Sustainable Design Reuse: Integrating Biomimicry and Parametric Thinking in Architectural Education. [PDF]

Biomimetics (Basel)
Semlali A, Tamzini S, Cazacova L.
europepmc   +1 more source

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

Advanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri, Boobash Raj Selvadurai, Nitin Gupta, Arturo Simoni‐Nieves, Alessandro Genna, Moshit Lindzen, Rishita Chatterjee, Marieke Van Daele, Deepthi Ramesh Kumar, Mirie Zerbib, Roni Oren, Isabelle Sophie Meijer, Elisabeth Franziska Wippich, Yahel Avraham, Rony Dahan, Yuya Haga, Laura E. Kilpatrick, Simon Platt, Stephen J. Hill, Lipika R. Pal, Eytan Ruppin, Yasuo Tsutsumi, Eliane Hadas Yardeni, Muhammad Abu Ahmad, Olga Radinsky, Donatella Romaniello, Mattia Lauriola, Angel Porgador, Yosef Yarden   +28 more
wiley   +1 more source

Virtual design studio

, 2006
Introduction to the Virtual Village / Jerzy Wojtowicz ...
openaire   +1 more source