Results 31 to 40 of about 640,551 (303)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Engagement of vulnerable communities in HIV prevention research in India: a qualitative investigation

Research Involvement and Engagement
Background Meaningful community engagement (CE) in HIV prevention research is crucial for successful and ethically robust study implementation. We conducted a qualitative study to understand the current CE practices in HIV prevention research and to ...
Venkatesan Chakrapani, Vijayalakshmi Loganathan, Paromita Saha, Devi Leena Bose, Nabeela Khan, Tiara Aurora, Jyoti Narayan, Joyeeta Mukherjee, Saif ul Hadi, Chitrangna Dewan   +9 more
doaj   +1 more source

Dissemination of innovative teaching and learning practice : the global studio [PDF]

, 2009
This project aims to disseminate teaching and learning resources from an innovative programme called the Global Studio to the ADM-HEA community. The area of innovation developed in the Global Studio was to link student teams across the globe in ‘designer’
Bohemia, Erik, Harman, Kerry
core  

Designing for Ballet Classes: Identifying and Mitigating Communication Challenges Between Dancers and Teachers [PDF]

, 2019
Dancer-teacher communication in a ballet class can be challenging: ballet is one of the most complex forms of movements, and learning happens through multi-faceted interactions with studio tools (mirror, barre, and floor) and the teacher. We conducted an
Birk K., Cao Z., Hachimura K., Johnston D., Kruszewski P., Marquardt Z., Montag J., Radell S.A., Radell S.A., Rizzo A., Trajkova M., Trajkova M., Trajkova M.   +12 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Can grey ravens fly? Beyond Frayling's categories [PDF]

, 2013
This paper analyses the effect of Christopher Frayling's (1993) categorisation of artistic research ‘research into art and design, research through art and design and research for art and design’ on the debate surrounding the efficacy of studio-based ...
Elkins J, Foucault M, Mottram J, Read H, Schön DA, United Kingdom Council for Graduate Education   +5 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peningkatan Efektivitas Pembelajaran Kelas Studio Online Dengan Metode Studiogogi Modul S.O.L.E

Cakrawala: Jurnal Pendidikan, 2021
Interactive learning is one of the most challenging studio design class lecturers, especially in virtual learning classes. Interactive learning could activate the student’s participation during the studio class activity.
Hanif Azhar
doaj   +1 more source

Management into design education: a case study [PDF]

, 2005
The design project set in a studio learning environment remains central to much of the under- graduate curriculum activity for the aspiring architect. Yet much recent discussion has identified the need to look beyond this design curriculum horizon and to
Beacock, Peter, Daws, Michael
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source