Results 41 to 50 of about 10,346,027 (303)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, Volume 20, Issue 11, Page 2918-2935, November 2026.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

DIFFERENT EDUCATIONAL APPROACHES IN DESIGN STUDIO

Iconarp International Journal of Architecture and Planning, 2020
Purpose In the architectural design studio education, series of approaches, such as vertical, traditional, constructivist or virtual, are executed.
Begüm Erçevik Sönmez
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, Volume 20, Issue 11, Page 2820-2838, November 2026.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

An ethnography of the design studio: Exploring social interactions and performances in studio environment through Goffman’s dramaturgical approach

, 2019
This paper aims to disclose undercurrents of in-class interactions and provide a deeper understanding of the social interactions and performances in the design studio.
Süleyman Karabulut, Celikoglu, Ozge Merzali, Karabulut, Süleyman Enes, Ozge Celikoglu, Celikoglu, Ozge, Karabulut, Süleyman   +5 more
core   +1 more source

London lost and found [PDF]

, 2017
The article reflects on the studio project of 2016-2017, set in Lower Marsh, Waterloo. It looks at London's lost buildings and how developers and architects are quick to gentrify areas that have been neglected using pre-design plans that slot into a ...
David Morris Design Exchange, Newman, Kaye   +1 more
core   +3 more sources

Playful absence / absence of play:: rethinking the design studio in online environments [PDF]

, 2021
While the pandemic has had a tremendous negative impact on societies, it has nonetheless provided us with a sort of living lab for investigating and exposing consolidated models of design education.
Gatto, Gionata, Khamisani, Noorin, Lehtonen, Miikka   +2 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Issues related to conducting a global studio [PDF]

, 2008
The purpose of this paper is to initiate discussion and guide a proposed workshop on issues in crossinstitutional and cross-disciplinary design studios, with a focus on assessment.
Harman, Kerry, Bohemia, Erik, Lauche, Kristina   +2 more
core  

Is the Design Studio Dead? - An International Perspective on the Changing Shape of the Physical Studio across Design Domains

, 2021
The process of moving the physical design studio experience, where social interaction is a guiding principle, into a detached virtual environment during the Covid pandemic has prompted design educators to re-evaluate what constitutes a traditional studio-
Fleischmann, Katja
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source