Results 41 to 50 of about 9,938,570 (303)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The Connectivist Design Studio [PDF]
, 2021 The design studio is the core element in the design curriculum where students gain key knowledge and skills. Typically implementing a project-based approach, it is characterised by learning by doing, collaborative learning and a prominent studio culture.
Petrova, Miroslava +1 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Issues related to conducting a global studio [PDF]
, 2008 The purpose of this paper is to initiate discussion and guide a proposed workshop on issues in crossinstitutional and cross-disciplinary design studios, with a focus on assessment.
Harman, Kerry +2 more
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SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source
Peningkatan Efektivitas Pembelajaran Kelas Studio Online Dengan Metode Studiogogi Modul S.O.L.E
Cakrawala: Jurnal Pendidikan, 2021 Interactive learning is one of the most challenging studio design class lecturers, especially in virtual learning classes. Interactive learning could activate the student’s participation during the studio class activity.
Hanif Azhar
doaj +1 more source
Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran +13 more
wiley +1 more source
ComplexityThis study, employing convenience sampling of art specialists, investigates the emotional resonance of young consumers with Chinese bamboo patterns, underscoring their significance in the realm of contemporary design.
Muxing Gao, Xiaoxiao Cao, Lihuai Qian
doaj +1 more source
Experimental Design in the Cultural Space Interior Design Studio: Linear Programmatic versus Holistic Mind-mapping Approach [PDF]
, 2011 Since its development into an independent university-based programme, interior design has drawn from the arts and engineering disciplines in the formulation of its pedagogical approach.
Thamrin, Diana
core +1 more source