Designer Drugs: A Synthetic Catastrophe. [PDF]
J Reward Defic Syndr, 2015 Fratantonio J, Andrade L, Febo M.
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Designer drugs 2015: assessment and management. [PDF]
Addict Sci Clin Pract, 2015 Weaver MF, Hopper JA, Gunderson EW.
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Synthetic Cathinone and Cannabinoid Designer Drugs Pose a Major Risk for Public Health. [PDF]
Front Psychiatry, 2017 Weinstein AM +3 more
europepmc +1 more source
Designer Tridentate Mucin 1 Aptamer for Targeted Drug Delivery
, 2012 Lihan Tan +4 more
openalex +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice. [PDF]
Genesis, 2016 Zhu H +7 more
europepmc +1 more source
Innenrücktitelbild: Cavitand‐Grafted Silicon Microcantilevers as a Universal Probe for Illicit and Designer Drugs in Water (Angew. Chem. 35/2014) [PDF]
, 2014 Elisa Biavardi +8 more
openalex +1 more source