Results 41 to 50 of about 7,754 (200)
Pharmaceuticals, 2023 Chronic use of antihistamines can induce abnormalities in lipid absorption with potential excessive accumulation of lipids in the mesentery that can lead to the development of obesity and a metabolic syndrome. The focus of the present work was to develop
Eman M. Mohamed +5 more
doaj +1 more source
Oxaziridines: Versatile Reagents in Modern Organic Synthesis
The Chemical Record, EarlyView.Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra +2 more
wiley +1 more source
Allergy, EarlyView.ABSTRACT Background To achieve adequate symptom control, patients with allergic rhinitis (AR) often need to increase their medication dose or add other treatments (co‐medication). We aimed to perform a systematic review to compare the efficacy and safety of AR medications for increased dose versus co‐medication.
Bernardo Sousa‐Pinto +44 more
wiley +1 more source
Antihistamines in the treatment of allergic rhinitis in children
Zdorovʹe Rebenka, 2018 The review of the literature provides current information about the clinical efficacy, safety and tolerability of the classic second-generation H1-antihistamine, desloratadine, in the treatment of allergic rhinitis in children.
A.E. Abaturov +2 more
doaj +1 more source
Allergy, EarlyView.This is the first randomised placebo‐controlled trial of intralymphatic immunotherapy using a microcrystalline tyrosine‐adjuvanted grass pollen allergoid. Three ultrasound‐guided ILIT injections were well tolerated and reduced combined symptom‐medication scores compared with placebo. The findings support further optimisation and clinical development of
Lara Šošić +13 more
wiley +1 more source
Signal Messages in Pediatric Practice
Безопасность и риск фармакотерапии, 2018 . Detection and analysis of drug safety signals in children is a mandatory part of pharmacovigilance. The criteria for evaluating signals of adverse effects were considered.
G. V. Kutekhova +6 more
doaj +1 more source
Evaluation of Thermal-Induced Polymorphic Transformation on Desloratadine and Desloratadine-Benzoic Acid Salt [PDF]
Pharmaceutical Sciences, 2020 Background: Active pharmaceutical ingredients face a challenge in manufacturing due to adverse physicomechanical properties. Desloratadine (DES) form I exhibits poor mechanical behavior through the formation of capping during the tableting process. Salt formation from DES and benzoic acid (BA) has been observed to resolve poor mechanical properties ...
Ahmad Ainurofiq +3 more
openaire +2 more sources
Journal of Cutaneous Pathology, EarlyView.ABSTRACT Dermatitis herpetiformis (DH) is a rare, intensely pruritic cutaneous manifestation of celiac disease (CD), typically presenting with excoriated papulovesicular lesions on extensor surfaces. DH is associated with IgA autoantibodies against epidermal transglutaminase (eTG), which form granular immune deposits in the papillary dermis and induce ...
Jeffrey Damman +5 more
wiley +1 more source
Research Results in PharmacologyIntroduction: Transdermal delivery of antihistamines is one of the ways to treat and prevent allergic conditions, reducing the adverse effects associated with oral administration. Materials and Methods: We evaluated the cytotoxicity of the transdermal
Ekaterina P. Brodovskaya +12 more
doaj +1 more source
Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria
Journal of the European Academy of Dermatology and Venereology, EarlyView.This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran +2 more
wiley +1 more source