Results 1 to 10 of about 6,251 (206)

Investigation of the Anti-Toxoplasma gondii Potential of Loratadine [PDF]

Pathogens
Toxoplasmosis remains a major global health concern, particularly in immunocompromised individuals and pregnant women, while currently available therapies are associated with significant toxicity and limited efficacy against chronic infection.
Stephanie Ortega Alves, Ingrid de Oliveira Dias, Gabriel Candido Moura, Samuel Cota Teixeira, Juliana Quero Reimão   +4 more
doaj   +3 more sources

Some Variables Affecting the Formulation of Oral Loratadine Suspension

Iraqi Journal of Pharmaceutical Sciences, 2017
Loratadine is a long acting non-sedating anti-histaminic agent that was developed for the treatment of seasonal allergic rhinitis, whose anti-histaminic action is more effective than the other anti-histaminic drugs available commercially.
Hala S.Yousif, Yehia I. Khalil
doaj   +4 more sources

A Systematic Review and Meta-Analysis of Loratadine Combined With Montelukast for the Treatment of Allergic Rhinitis

Frontiers in Pharmacology, 2023
Background: Loratadine and montelukast are clinical first-line drugs in the treatment of allergic rhinitis (AR). However, there is no clear evidence of the efficacy of loratadine combined with montelukast in the treatment of AR.
Chao Liao
exaly   +3 more sources

Repurposing loratadine to induce ferroptosis and overcome multidrug resistance: preclinical evidence in KB-V-1 cells [PDF]

Frontiers in Oncology
BackgroundMDR1/P-glycoprotein-mediated multidrug resistance (MDR) limits chemotherapy efficacy across many cancers. Ferroptosis, an iron-dependent regulated cell death driven by lipid peroxidation, offers a potential strategy to bypass MDR.
Nicholas Cook, Xin Li, Nathan J. Bowen, Alira Danaher, MaKayla Thomas, Saani Alhassan, Briah Arms, Daqing Wu, Daqing Wu   +8 more
doaj   +2 more sources

Repurposing loratadine to reverse colistin resistance in Klebsiella pneumoniae through targeting lipid A modification [PDF]

Emerging Microbes and Infections
The emergence of multidrug-resistant Klebsiella pneumoniae poses a significant challenge to clinical treatment and public health. Strategies combining antibiotics with FDA-approved non-antibiotic drugs have recently attracted attention as a promising ...
Xiaoying Wu, Zhanzhe Ge, Haojie Zhan, Mengxiang Zheng, Yiming Feng, Yajun Zhai, Li Yuan, Jianhua Liu, Yushan Pan, Gongzheng Hu, Xiaoyuan Ma, Dandan He   +11 more
doaj   +2 more sources

Loratadine inhibits Staphylococcus aureus virulence and biofilm formation

iScience, 2022
Summary: There are no anti-virulence and anti-biofilm treatments for Staphylococcus aureus infection. We found that 25 μM loratadine inhibits S. aureus biofilm formation under static or flow-based conditions. Testing of loratadine effects on 255 clinical
Jinxin Zheng, Yongpeng Shang, Yang Wu, Yuxi Zhao, Zhong Chen, Zhiwei Lin, Peiyu Li, Xiang Sun, Guangjian Xu, Zewen Wen, Junwen Chen, Yu Wang, Zhanwen Wang, Yanpeng Xiong, Qiwen Deng, Di Qu, Zhijian Yu   +16 more
doaj   +1 more source

Loratadine-associated cystoid macular edema: A case report

American Journal of Ophthalmology Case Reports, 2022
Purpose: To report the first known case of bilateral cystoid macular edema in a patient undergoing long-term loratadine treatment. Observations: A 49-year-old Chinese woman who had been undergoing treatment with loratadine for the past 6 years presented ...
Yong Tang, Rui Dou, Yuyan Liu, Shiyong Xie, Quanhong Han   +4 more
doaj   +1 more source

Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness

Journal of Pharmacological Sciences, 2022
T cells play an essential role in the development of allergen-induced nasal hyperresponsiveness (NHR), a pathophysiological response in allergic rhinitis.
Naoto Uda, Sawako Ogata, Norimasa Yamasaki, Shuka Miura, Naohisa Hosomi, Akio Mori, Minoru Gotoh, Kento Miura, Osamu Kaminuma   +8 more
doaj   +1 more source

THE DEVELOPMENT AND VALIDATION OF IDENTIFICATION METHODS OF LORATADINE TABLETS

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
Methods of identification of loratadine in tablets by absorption spectrophotometry, TLC and qualitative reaction (based on hydroxamic reaction) have been developed and validated.
D. B. Korobko, O. B. Poliak, L. S. Logoida, N. O. Zarіvna, O. V. Sem’ianіv   +4 more
doaj   +1 more source

Onset of action for loratadine tablets for the symptomatic control of seasonal allergic rhinitis in adults challenged with ragweed pollen in the Environmental Exposure Unit: a post hoc analysis of total symptom score

Allergy, Asthma & Clinical Immunology, 2018
Background Loratadine is a second-generation, non-sedating antihistamine used for the relief of allergic rhinitis symptoms. Previous studies reported that when loratadine was encapsulated, the onset of action for symptom relief was 180 min.
Mark W. Tenn, Lisa M. Steacy, Charlene C. Ng, Anne K. Ellis   +3 more
doaj   +1 more source