Results 31 to 40 of about 6,251 (206)

Treatment Dose Increase Versus Co‐Medication in Allergic Rhinitis: Systematic Review With Dose–Response Network Meta‐Analysis

Allergy, EarlyView.
ABSTRACT Background To achieve adequate symptom control, patients with allergic rhinitis (AR) often need to increase their medication dose or add other treatments (co‐medication). We aimed to perform a systematic review to compare the efficacy and safety of AR medications for increased dose versus co‐medication.
Bernardo Sousa‐Pinto, Rafael José Vieira, Sara Gil‐Mata, Ana Margarida Pereira, Vítor Henrique Duarte, Antonio Bognanni, Manuel Marques‐Cruz, Paweł Jemioło, Mattia Giovannini, Danilo di Bona, Arnav Agarwal, Mark S. Dykewicz, Mohamed H. Shamji, Maria Jose Torres, Torsten Zuberbier, Ludger Klimek, Alexandro W. L. Chu, Holger J. Schünemann, Guido Schwarzer, João A. Fonseca, Jean Bousquet, on behalf of the ARIA 2024–2025 systematic reviews group, Ana Teixeira‐Ferreira, André Ferreira, António Cardoso‐Fernandes, Despo Ierodiakonou, Diana Portela, Ewa Borowiack, Ewelina Sadowska, Henrique Ferreira‐Cardoso, Hugo Viegas, Izabel Pera Calvi, João Castro‐Teles, José Laerte Boechat, Juliana Pereira‐Macedo, Maria Inês Torres, Marta Soares Pereira, Miguel Campos‐Lopes, Nuno Lourenço‐Silva, Pau Riera‐Serra, Paula Perestrelo, Raquel Albuquerque‐Costa, Renato Ferreira‐da‐Silva, Rita A. Silva Ribeiro, Tuuli Thomander   +44 more
wiley   +1 more source

SYNTHESIS AND EVALUATION OF TASTE-MASKED IONIC LIQUID SALTS OF LORATADINE [PDF]

, 2020
Objective: To synthesize and evaluate taste-masked ionic liquid (IL) salts of loratadine. Methods: In the present work, pharmaceutically active IL salts of loratadine using selected counter-ions were synthesized.
SAPKAL, NIDHI P., JAISWAL, NIDHI, GONDANE, PRADNYA   +2 more
core   +1 more source

Loratidine is associated with improved prognosis and exerts antineoplastic effects via apoptotic and pyroptotic crosstalk in lung cancer

Journal of Experimental & Clinical Cancer Research
Background Tumor-associated inflammation suggests that anti-inflammatory medication could be beneficial in cancer therapy. Loratadine, an antihistamine, has demonstrated improved survival in certain cancers.
Xiwen Liu, Ran Zhong, Jiaxing Huang, Zisheng Chen, Haoxiang Xu, Lixuan Lin, Qi Cai, Miao He, Shen Lao, Hongsheng Deng, Caichen Li, Jianfu Li, Yongmei Zheng, Xiaoyan Liu, Riqi Zeng, Jianxing He, Wenhua Liang   +16 more
doaj   +1 more source

Utilizing the NAG-4SX3-3D analyzer at 0-180 degree coupling with continuous flow injection analysis to determine of loratadine in drugs by the precipitation method using sodium nitroprusside [PDF]

Cellular, Molecular and Biomedical Reports
In order to improve the sensitivity of the newly established methodology, a thorough examination was carried out on the essential parameter. A rapid and highly responsive technique has been developed for the detection of loratadine.
Bakr Sadiq Mohammed, Nagham Shakir Turkey   +1 more
doaj   +1 more source

Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions.

PLoS Computational Biology, 2012
Drug-drug interactions (DDIs) are a common cause of adverse drug events. In this paper, we combined a literature discovery approach with analysis of a large electronic medical record database method to predict and evaluate novel DDIs.
Jon D Duke, Xu Han, Zhiping Wang, Abhinita Subhadarshini, Shreyas D Karnik, Xiaochun Li, Stephen D Hall, Yan Jin, J Thomas Callaghan, Marcus J Overhage, David A Flockhart, R Matthew Strother, Sara K Quinney, Lang Li   +13 more
doaj   +1 more source

Management of chronic urticaria: Current status and future prospect

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman, Mona Al‐Ahmad, Maryam Al‐Nesf, Chia‐Yu Chu, Luis Felipe Ensina, Ana M. Gimenez‐Arnau, Margarida Gonçalo, Clive Grattan, Michihiro Hide, Pavel Kolkhir, Martin Metz, Iman Nasr, Romi Saini, Simon Francis Thomsen, Torsten Zuberbier, Emek Kocaturk   +15 more
wiley   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Direct α‐C(sp3)─H Alkylation and Arylation of Ethers Enabled by Carbon Nitride/Nickel Metallaphotoredox Catalysis

ChemSusChem, Volume 19, Issue 20, 28 October 2026.
A recyclable carbon nitride/nickel metallaphotoredox platform enables direct α‐C(sp3)─H arylation and alkylation of ethers, amides, and benzylic substrates under visible light. Broad substrate scope, late‐stage functionalization, five‐cycle photocatalyst reuse, and continuous‐flow translation are demonstrated, while mechanistic studies support ...
Miguel M. de Vries Ibáñez, Nathan G. G. Husy, Elisabetta Inico, Kaan Karaca, Milla Vigliengo, Andrea Olivati, Annamaria Petrozza, Carlo Cavallotti, Gianvito Vilé   +8 more
wiley   +1 more source

Quality by Design Approach for a Multicomponent Quantification Using HPLC-PDA and HPLC-MS: Application to Dosage Form and Biological Body Fluids

Separations, 2022
A multicomponent pharmaceutical that contains loratadine, paracetamol, and pseudoephedrine was quantified using HPLC-PDA. The three analytes were well-separated and quantified in the dosage form on a C-18 column using a gradient mobile phase.
Naser F. Al-Tannak, Bashayer J. Al-Shatti, Abdullah S. Al Ali, A. Hemdan   +3 more
doaj   +1 more source

Versatile Detection of Cellular Protein via Fluorescence Anisotropy

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Cell Lysate Fluorescence Anisotropy (CFAST) utilizes long lifetime dye‐labeled nanobodies for rapid protein quantification in minimally purified, complex cell lysate. When coupled with cellular thermal shift, CFAST allows high‐throughput detection of endogenous protein‐small molecule engagement, facilitating the discovery of novel binders for ...
Qing Tang, Yuan‐Ping Wei, Ricky Ruiqi Ma, Na Wei, Tammy Zihan Zhou, Hilary Kung‐Yu Ho, Zafar Iqbal Bhat, Iqra Ishrat, Xiaoyu Li, Judy Wai Ping Yam, Yung Hou Wong, Qiankun Wang, Justin L. Tan   +12 more
wiley   +1 more source