Results 41 to 50 of about 6,251 (206)

Repurposing FDA-approved drugs to find a novel inhibitor of alpha-ketoglutarate-dependent dioxygenase FTO to treat esophageal cancer

Research in Pharmaceutical Sciences
Background and purpose: The Fat mass and obesity-associated protein (FTO) plays a significant role in esophageal cancer by regulating N6-methyladenosine (m6A) modification. FTO inhibition has shown potential in cancer therapies but remains underexplored.
Zeinab Mohammadi, Marie Saghaeian Jazi, Seyyed Mehdi Jafari, Seyyed Mostafa Mir, Jahanbakhsh Asadi, Massoud Amanlou   +5 more
doaj   +1 more source

Anti‐Allergic Potentials of Actinodaphne angustifolia: Integrated In Vivo Evaluation and In Silico Analysis of Bioactive Compounds

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Actinodaphne angustifolia leaf extract exhibited significant anti‐allergic activity in a TDI‐induced mouse model, reducing sneezing, nasal scratching, nasal scores, WBC counts, and serum IgE levels. The extract was non‐toxic and rich in bioactive polyphenols, particularly (−) epicatechin and rutin hydrate.
Rabindra Nath Acharyya, Md. Abid Muktadir Risha, Novi Dwi Widya Rini, Sarita Manandhar, Sabina Shahi, Biswa Nath Bhadra, Asish Kumar Das, Katsuhiko Ariga, Shrabanti Dev, Lok Kumar Shrestha   +9 more
wiley   +1 more source

Inflammatory Factors in Allergic Rhinitis: A 20‐Year Bibliometric Mapping and Emerging Trends

Flavour and Fragrance Journal, Volume 41, Issue 5, Page 1076-1089, September 2026.
This figure illustrates the bibliometric process and results of research on inflammatory factors of allergic rhinitis from 2004 to 2024 including data screening, global distribution, collaborative networks and the evolution of research hotspots. ABSTRACT Allergic rhinitis (AR) is driven by a network of inflammatory mediators released by mast cells ...
Shanshan Jing, Fengying Zhang, Qiqi Liu
wiley   +1 more source

Crocus sativus (Saffron) Aqueous Extract Mediated Green Synthesis of Iron Oxide Nanoparticles and Their In Vitro and In Vivo Biological Investigations

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
The Crocus sativus (saffron) aqueous extract mediated green synthesis of iron oxide nanoparticles and their in vitro and in vivo biological investigations. ABSTRACT The present study reports the green synthesis of iron oxide nanoparticles (IONPs) using the aqueous extract of Crocus sativus (saffron) as a natural reducing and stabilizing agent, followed
Abdur Rauf, Khurram Shehzad, Hira Naeem, Shahkar Usama, Zubair Ahmad, Bilal Khan, Naveed Muhammad, Muhammad Shafique, Yahya S. Al‐Awthan, Omar S. Bahattab, Mohammed Mansour Quradha   +10 more
wiley   +1 more source

Signal Messages in Pediatric Practice

Безопасность и риск фармакотерапии, 2018
. Detection and analysis of drug safety signals in children is a mandatory part of pharmacovigilance. The criteria for evaluating signals of adverse effects were considered.
G. V. Kutekhova, E. O. Zhuravleva, M. A. Darmostukova, I. I. Snegireva, N. Yu. Velts, R. N. Alyautdin, E. V. Shubnikova   +6 more
doaj   +1 more source

Formulation and Optimization of Orodispersible Tablet of Loratadine Using Box Behnken Design [PDF]

, 2019
In present study Orodispersible tablets (ORDT) of Loratadine were prepared and optimized. Solid dispersion of Loratadine- β cyclodextrin complex were prepared and used in preparation of Orodispersible tablets.
Kundawala, Aliasgar, Desai, Anjali, Chauhan, Khushbu, Patel, Pratik, Kapadia, Dhwani   +4 more
core   +1 more source

Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery [PDF]

, 2020
Aim: To prepare loratadine-loaded solid lipid nanoparticles (SLNs) using a modified two-step ultrasound-assisted phase inversion temperature (PIT) process. Results/methodology: Loratadine was dissolved in beeswax and Tween 80 was dissolved in water.
Shouqair, Douha, Amin, Muhammad, Sarheed, Omar, Ramesh, KVRNS, Boateng, Joshua, Drechsler, Markus   +5 more
core   +1 more source

Medication prescription patterns in cancer rehabilitation physiatry outpatients: A multicenter retrospective study

PM&R, Volume 18, Issue 9, Page 1005-1015, September 2026.
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen, Nafis Eghrari, David Leong, Philip Chang, Jasmine Zheng, Amy Ng, Richard Wilson, Mary Vargo   +7 more
wiley   +1 more source

In-Vitro Dissolution Profile Comparison of Fixed Dose Combination Suspension Containing Ibuprofen and Loratadine with Their Corresponding Marketed Suspensions

Liquids
(1) Background: Fixed-dose combination (FDC) improves patient convenience and therapeutic adherence by combining suitable drugs in a single dose form.
Muhammad Faheem, Lateef Ahmad, Muhammad Hashim   +2 more
doaj   +1 more source

EFFECTS OF LORATADINE ON CYTOSOLIC CA2+ LEVELS AND LEUKOTRIENE RELEASE - NOVEL MECHANISMS OF ACTION INDEPENDENT OF THE ANTIHISTAMINE ACTIVITY

, 1994
Loratadine, a non-sedating anti-histamine drug, displays in vitro potential anti-allergic properties not related to its interaction with the histamine H-1 receptor. In a search for the mechanisms of these actions, we have found that loratadine induces an
G. ROVATI, O. LETARI, S. NICOSIA, A. MIOZZO, P. BELLONI, G. FOLCO, A. SALA   +6 more
core   +1 more source