Results 161 to 170 of about 18,110 (202)
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Current Opinion in Neurology, 1997
Desmin-related myopathies are marked by accumulation of desmin, which is often familial and associated with cardiomyopathy. When multifocal this excess is characterized by inclusions such as cytoplasmic or spheroid bodies, when disseminated the excess is called granulofilamentous material.
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Desmin-related myopathies are marked by accumulation of desmin, which is often familial and associated with cardiomyopathy. When multifocal this excess is characterized by inclusions such as cytoplasmic or spheroid bodies, when disseminated the excess is called granulofilamentous material.
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Desmin Filaments and Desmin-Related Myopathy
2015Desmin is the major intermediate filament protein in muscle tissue. In skeletal and cardiac muscle, desmin filaments distribute in the intermyofibrillar space to link adjacent myofibrils to each other at the z disc level, to the sarcolemma via costameres and sarcoglycan-dystroglycan complexes, and insert into to the nuclear envelope.
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Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1987
1. A new mechanism is proposed for the dehydration of desmine, according to which dissociation of some of the water molecules coordinated with the calcium cations occurs to form hydroxyls after a certain stage. 2. It has been established that the processes of hydroxyl formation and dehydroxylation are the reasons for the irreversible ...
J. I. Mirzai +4 more
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1. A new mechanism is proposed for the dehydration of desmine, according to which dissociation of some of the water molecules coordinated with the calcium cations occurs to form hydroxyls after a certain stage. 2. It has been established that the processes of hydroxyl formation and dehydroxylation are the reasons for the irreversible ...
J. I. Mirzai +4 more
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Desmin at myotendinous junctions
Experimental Cell Research, 1992Myofibrils are linked to the cell membrane at myotendinous junctions located at the ends of muscle fibers, and at costameres, sites positioned periodically along lateral surfaces of muscle cells. Both of these sites are enriched in proteins that link active components of myofibrils to the cell membrane.
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Osteogenic Melanoma With Desmin Expression
The American Journal of Dermatopathology, 2017Background: Osteogenic differentiation is rarely seen in melanomas, when it occurs it is mainly in acral lesions. Methods: We report a case of an osteogenic melanoma in a 49-year-old woman who presented with a pigmented lesion in the subungueal region of her left hallux.
Flávia, Trevisan +8 more
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1999
Abstract Desmin belongs to the intermediate filament family of proteins. Protein sequence homology and intron placement of the desmin gene classify desmin as a type Ill IF protein, together with vimentin, peripherin, and giial fibrillary acidic protein.
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Abstract Desmin belongs to the intermediate filament family of proteins. Protein sequence homology and intron placement of the desmin gene classify desmin as a type Ill IF protein, together with vimentin, peripherin, and giial fibrillary acidic protein.
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Desmin‐related neuromuscular disorders
Muscle & Nerve, 1995AbstractDesmin, the intermediate filament protein of skeletal muscle fibers, cardiac myocytes, and certain smooth muscle cells, is a member of the cytoskeleton linking Z‐bands with the plasmalemma and the nucleus. The pathology of desmin in human neuromuscular disorders is always marked by increased amounts, diffusely or focally.
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Desmin pathology in neuromuscular diseases
Virchows Archiv B Cell Pathology Including Molecular Pathology, 1993Desmin is an intermediate filament protein that in striated muscle is normally located at Z-bands, beneath the sarcolemma, and prominently at neuromuscular junctions. It is abundant during myogenesis and in regenerating fibers, but decreases in amount with maturation; in regenerating and denervated muscle fibers it is co-expressed with vimentin ...
H H, Goebel, A, Bornemann
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Experimental Cell Research, 2011
Disorganization of the desmin network is associated with cardiac and skeletal myopathies characterized by accumulation of desmin-containing aggregates in the cells. Multiple associations of intermediate filament proteins form a network to increase mechanical and functional stability. Synemin is a desmin-associated type VI intermediate filament protein.
Chourbagi O. +6 more
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Disorganization of the desmin network is associated with cardiac and skeletal myopathies characterized by accumulation of desmin-containing aggregates in the cells. Multiple associations of intermediate filament proteins form a network to increase mechanical and functional stability. Synemin is a desmin-associated type VI intermediate filament protein.
Chourbagi O. +6 more
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[Desmin-related cardiomyopathy].
Arkhiv patologii, 2011The observation of 26 years old patient with desminopathy declared itself by hypertrophied cardiomyopathy with its transformation into restrictive phenotype is presented. The features of pathologic course at the patient were a dominance and diversity of cardiac manifestations.
M G, Rybakova +4 more
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