Results 71 to 80 of about 8,758 (225)

Toward Timely Diagnosis of Pancreatic Cancer: Revolutionizing Early Detection Through Genomics, Artificial Intelligence, and Noninvasive Biomarkers

Journal of Gastroenterology and Hepatology, Volume 41, Issue 3, Page 895-913, March 2026.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive cancers, typically diagnosed at an advanced stage due to its subtle and often absent early symptoms. Despite representing only 3% of new cancer cases, it is projected to become the second leading cause of cancer‐related deaths by 2030.
Muhammad Masroor Hussain, Sana Qammar, Ju‐Mei Wang, Ao‐Qiang Zhai, Fu‐yu Li, Hai‐jie Hu   +5 more
wiley   +1 more source

Undifferentiated Embryonal Sarcoma of the Liver in a 6 Years Old Male Patient: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Undifferentiated Embryonal Sarcoma of the Liver (UESL) is a rare, aggressive mesenchymal tumor predominantly affecting children. Its non‐specific clinical presentation and variable imaging characteristics often lead to diagnostic delays and complex management.
Rajab Msemo, Michael Machage, Novath Ngowi, Alex Mashaka, Elizabeth Sawaki, Ally Mwanga   +5 more
wiley   +1 more source

Aggressive fibromatosis of the head and neck: a new classification based on a literature review over 40 years (1968-2008) [PDF]

, 2010
BACKGROUND: Fibromatosis is an aggressive fibrous tumor of unknown etiology that is, in some cases, lethal. Until now, there has been no particular classification for the head and neck.
A Azzarelli, A Gronchi, A Humar, A Leithner, AJ Chalmers, AP Stout, AP Stout, AR Bhaskar, Astrid L. Kruse, C Gebert, CA Kingston, CB Fowler, D Santis De, F Fritzmeier, FM Enzinger, H Lackner, H Qi, HC Park, Heinz T. Luebbers, I Wever De, J Conley, J Mace, J Styczynski, JD Raguse, JJ Reitamo, JJ Reitamo, JK Masson, Joachim A. Obwegeser, JR Benson, JT Plukker, Klaus W. Grätz, LB Faulkner, MA Spear, MC Heinrich, MC Posner, MS Turner, P Hayry, P Scougall, PM Tostevin, PW Allen, RT Hunt, S Buitendijk, SE Lakhan   +42 more
core   +1 more source

Cytologic and Histologic Findings of Extrapleural Solitary Fibrous Tumor: Report of Two Cases

Diagnostic Cytopathology, Volume 54, Issue 2, Page E46-E53, February 2026.
ABSTRACT Solitary fibrous tumors (SFT) are a rare neoplasm of mesenchymal origin. SFT was previously described primarily in the pleura and meninges; however, extrapleural and extra‐meningeal SFT have been reported in almost every anatomic site and account for up to 40% of cases.
Michael Tyler, Katsiaryna Khatskevich, Chadi Hajar, Jack Yang, Hao Liu   +4 more
wiley   +1 more source

Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development. [PDF]

, 2015
BackgroundAdenomatous polyposis coli (Apc) is a tumor suppressor that inhibits Wnt/Ctnnb1. Mutations of Apc will not only lead to familial adenomatous polyposis with associated epithelial lesions, but will also cause aggressive fibromatosis in ...
Bellusci, Saverio, Chen, Hui, Chiu, Joanne, El Agha, Elie, Luo, Yongfeng, Menke, Douglas B, Qian, Bang-Ping, Shi, Wei, Turcatel, Gianluca, Warburton, David   +9 more
core   +1 more source

Small Nucleotide Variant Analysis Using RNA Fusion Panel (SMURF): Making the Most of RNAseq Data in Solid Tumours

Journal of Clinical Laboratory Analysis, Volume 40, Issue 4, February 2026.
RNA‐based fusion panels using targeted next‐generation sequencing of formalin‐fixed paraffin‐embedded (FFPE) tumour tissue specimens have been used for a few years from patients with various tumour types to detect rearrangements/fusions. Using the bioinformatic approaches the data obtained from RNA sequencing (RNAseq) can also be used for small ...
Pranav Dorwal, Julie Robin, Broden Krause, Patricia Pyrchla, Bin Yuan, Robert Quach, Anna Fong Na Goh, Pamela Htain, Noel Djitro, Amit Kumar, Liyan Song, Priscillia Siswara, Suzanne Svobodova, Peter Kaub, Beena Kumar   +14 more
wiley   +1 more source

Children and Adolescents With Localised Non‐Rhabdomyosarcoma Soft Tissue Sarcoma: Results of the CWS‐96 and CWS‐2002P Prospective Trials With Reclassification of the Trial Data Incorporating the Recent Soft Tissue Sarcoma Registry

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Background Here we report the results of the first comprehensive European trials for all soft tissue sarcoma entities, which aimed to develop a new risk stratification system, limit radiotherapy and chemotherapy for low‐/standard‐risk patients, and evaluate different chemotherapy regimens for high‐risk patients.
Amadeus T. Heinz, Anton Schönstein, Ewa Koscielniak, Martin Ebinger, Jörg Fuchs, Semi Harrabi, Christian Vokuhl, Roland Imle, Sabine Stegmaier, Ines B. Brecht, Gustaf Ljungman, Hanna Juntti, Ruth Ladenstein, Bernarda Kazanowska, Thomas Klingebiel, Kristian W. Pajtler, Monika Sparber‐Sauer   +16 more
wiley   +1 more source

Identification of heterogeneity among soft tissue sarcomas by gene expression profiles from different tumors [PDF]

, 2008
The heterogeneity that soft tissue sarcomas (STS) exhibit in their clinical behavior, even within histological subtypes, complicates patient care. Histological appearance is determined by gene expression.
Skubitz Amy PN, Manivel J Carlos, Pambuccian Stefan, Skubitz Keith M   +3 more
core   +2 more sources

Phase II clinical trial of nirogacestat in patients with relapsed ovarian granulosa cell tumours

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Evidence suggests NOTCH activation is among the survival and proliferation pathways interacting with FOXL2 c.402C > G (p.Cys134Trp) mutation in granulosa cell tumours (GCT). This Phase II clinical trial of nirogacestat in GCT achieved its enrolment target in < 1 year and primary analysis within 2 years.
Rachel N. Grisham, Elizabeth Hopp, Kathryn Pennington, Robert Holloway, Robert M. Wenham, Pawel Blecharz, Lauren Dockery, Koji Matsuo, Ritu Salani, Mariusz Bidzinski, Patricia Braly, Paul Celano, Thomas Reid, Shelly Seward, Jocelyn Lewis, Mark Johnson, Robert DuBose, Sarah Ahn, Shinta Cheng, Carmelita Alvero, Panagiotis A. Konstantinopoulos   +20 more
wiley   +1 more source

In the Beginning There Was Colectomy: Current Surgical Options in Familial Adenomatous Polyposis [PDF]

, 2004
Multiple colonic polyps, almost guaranteed colorectal cancer by the age of forty-five and an increased risk of non-colonic cancers characterise the autosomal dominant condition Familial Adenomatous Polyposis (FAP) 1.
McGrath Daniel R, Spigelman Allan D
core   +2 more sources