Results 11 to 20 of about 10,499 (199)

Desmoplakin and clinical manifestations of desmoplakin cardiomyopathy

Chinese Medical Journal, 2021
. Desmoplakin (DSP), encoded by the DSP gene, is the main desmosome component and is abundant in the myocardial tissue. There are three DSP isoforms that assume the role of supporting structural stability through intercellular adhesion. It has been found
Zhong-Yu Yuan, Li-Ting Cheng, Ze-Feng Wang, Yong-Quan Wu, Ning-Ning Wang   +4 more
doaj   +1 more source

Paraneoplastic Pemphigus Autoantibodies Against C-terminus of Desmoplakin Induced Acantholysis In Vitro and In Vivo

Frontiers in Immunology, 2022
Paraneoplastic pemphigus (PNP) is an autoimmune bullous disease associated with underlying neoplasms and characterized by antibodies against desmoglein 3 (Dsg 3) and plakins.
Xue Wang, Xue Wang, Xue Wang, Xue Wang, Rui Wang, Rui Wang, Rui Wang, Dingfang Bu, Leyi Wang, Leyi Wang, Leyi Wang, Yuexin Zhang, Yuexin Zhang, Yuexin Zhang, Yuan Chang, Yuan Chang, Yuan Chang, Chenyang Zhang, Chenyang Zhang, Xixue Chen, Xixue Chen, Xixue Chen, Xuejun Zhu, Xuejun Zhu, Xuejun Zhu, Zhi Liu, Mingyue Wang, Mingyue Wang, Mingyue Wang   +28 more
doaj   +1 more source

Desmoplakin cardiomyopathy: case report. [PDF]

Eur Heart J Case Rep
Helal A, Alama M, Ali W, Farooq M.
europepmc   +2 more sources

Humanized Dsp ACM Mouse Model Displays Stress-Induced Cardiac Electrical and Structural Phenotypes

Cells, 2022
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by fibro-fatty infiltration with an increased propensity for ventricular arrhythmias and sudden death. Genetic variants in desmosomal genes are associated with ACM.
Tyler L. Stevens, Heather R. Manring, Michael J. Wallace, Aaron Argall, Trevor Dew, Peter Papaioannou, Steve Antwi-Boasiako, Xianyao Xu, Stuart G. Campbell, Fadi G. Akar, Maegen A. Borzok, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig, Mona El Refaey   +14 more
doaj   +1 more source

Sinus arrest in a p.Arg160X-DSP-positive patient without evidence of desmoplakin-mediated cardiomyopathy: a case report

Frontiers in Cardiovascular Medicine, 2023
BackgroundPathogenic/Likely pathogenic variants in DSP-encoded desmoplakin are strongly associated with arrhythmogenic cardiomyopathy (ACM). However, their contribution towards sinus node dysfunction has not been well-delineated.Case summaryA 74-year-old
Nicholas Y. Tan, John R. Giudicessi, Jason R. Harvey, Samuel J. Asirvatham, Konstantinos C. Siontis   +4 more
doaj   +1 more source

Desmoplakin interacts with the coil 1 of different types of intermediate filament proteins and displays high affinity for assembled intermediate filaments. [PDF]

PLoS ONE, 2018
The interaction of intermediate filaments (IFs) with the cell-cell adhesion complexes desmosomes is crucial for cytoskeletal organization and cell resilience in the epidermis and heart.
Bertrand Favre, Nadja Begré, Jamal-Eddine Bouameur, Prakash Lingasamy, Gloria M Conover, Lionel Fontao, Luca Borradori   +6 more
doaj   +1 more source

Desmosomal Junctions and Connexin-43 Remodeling in High-Pacing-Induced Heart Failure Dogs

Anatolian Journal of Cardiology, 2023
Background: While desmosomal junctions and gap junction remodeling are among the arrhythmogenic substrates, the fate of desmosomal and gap junctions in high-pacing-induced heart failure remains unclear. This aim of this study was to determine the fate of
Qing Wang, Liang Xiaoyan, Shuai Shang, Yongqiang Fan, Huasheng Lv, Baopeng Tang, Yanmei Lu   +6 more
doaj   +1 more source

Cortical tension regulates desmosomal morphogenesis

Frontiers in Cell and Developmental Biology, 2022
Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton.
Marcin Moch, Jana Schieren, Rudolf E. Leube   +2 more
doaj   +1 more source

FDG PET/CT imaging and circulating biomarkers of inflammation in desmoplakin cardiomyopathy. [PDF]

ESC Heart Fail
Abstract Aims Inflammation has been implicated in the pathogenesis of desmoplakin (DSP) cardiomyopathy, and retrospective studies have described abnormal myocardial fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) findings in symptomatic patients eventually diagnosed with DSP cardiomyopathy.
Divakaran S, Randhawa V, Tahir UA, Robertson M, Waheed AA, Perillo A, Barrett L, Blankstein R, Feinberg MW, Di Carli MF, Lakdawala NK.   +10 more
europepmc   +2 more sources

Genetic deletion of the desmosomal component desmoplakin promotes tumor microinvasion in a mouse model of pancreatic neuroendocrine carcinogenesis. [PDF]

PLoS Genetics, 2010
We used the RIP1-Tag2 (RT2) mouse model of islet cell carcinogenesis to profile the transcriptome of pancreatic neuroendocrine tumors (PNET) that were either non-invasive or highly invasive, seeking to identify pro- and anti-invasive molecules ...
Matthew G H Chun, Douglas Hanahan
doaj   +1 more source