Results 41 to 50 of about 11,754 (266)

Desmoplakin cardiomyopathy: case report. [PDF]

Eur Heart J Case Rep
Abstract Background Desmoplakin (DSP) cardiomyopathy is a distinct form of cardiomyopathy characterized by frequent left ventricular involvement with extensive fibrosis, high arrhythmic risk, and episodes of acute myocardial injury. Case summary
Helal A, Alama M, Ali W, Farooq M.
europepmc   +3 more sources

Desmosomal Junctions and Connexin-43 Remodeling in High-Pacing-Induced Heart Failure Dogs

Anatolian Journal of Cardiology, 2023
Background: While desmosomal junctions and gap junction remodeling are among the arrhythmogenic substrates, the fate of desmosomal and gap junctions in high-pacing-induced heart failure remains unclear. This aim of this study was to determine the fate of
Qing Wang, Liang Xiaoyan, Shuai Shang, Yongqiang Fan, Huasheng Lv, Baopeng Tang, Yanmei Lu   +6 more
doaj   +1 more source

Imaging features of desmoplakin arrhythmogenic cardiomyopathy: A comparative cardiovascular magnetic resonance study. [PDF]

J Cardiovasc Magn Reson
Laredo M, Charpentier E, Soulez S, Nguyen V, Martino A, Calò L, Ader F, Hermida A, Fressart V, Charron P, Kachenoura N, Gandjbakhch E, Redheuil A.   +12 more
europepmc   +2 more sources

Desmoplakin interacts with the coil 1 of different types of intermediate filament proteins and displays high affinity for assembled intermediate filaments. [PDF]

PLoS ONE, 2018
The interaction of intermediate filaments (IFs) with the cell-cell adhesion complexes desmosomes is crucial for cytoskeletal organization and cell resilience in the epidermis and heart.
Bertrand Favre, Nadja Begré, Jamal-Eddine Bouameur, Prakash Lingasamy, Gloria M Conover, Lionel Fontao, Luca Borradori   +6 more
doaj   +1 more source

Desmoplakin Cardiomyopathy: Myocarditis-Like Episodes [PDF]

Cureus
Fatrous T, Ibzea S, Zahir Hussain S.
europepmc   +2 more sources

Cortical tension regulates desmosomal morphogenesis

Frontiers in Cell and Developmental Biology, 2022
Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton.
Marcin Moch, Jana Schieren, Rudolf E. Leube   +2 more
doaj   +1 more source

Genetic deletion of the desmosomal component desmoplakin promotes tumor microinvasion in a mouse model of pancreatic neuroendocrine carcinogenesis. [PDF]

PLoS Genetics, 2010
We used the RIP1-Tag2 (RT2) mouse model of islet cell carcinogenesis to profile the transcriptome of pancreatic neuroendocrine tumors (PNET) that were either non-invasive or highly invasive, seeking to identify pro- and anti-invasive molecules ...
Matthew G H Chun, Douglas Hanahan
doaj   +1 more source

A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriers. [PDF]

Eur Heart J
Background and Aims Pathogenic desmoplakin (DSP) gene variants are associated with the development of a distinct form of arrhythmogenic cardiomyopathy known as DSP cardiomyopathy.
Carrick RT, Gasperetti A, Protonotarios A, Murray B, Laredo M, van der Schaaf I, Dooijes D, Syrris P, Cannie D, Tichnell C, Gilotra NA, Cappelletto C, Medo K, Saguner AM, Duru F, Hylind RJ, Abrams DJ, Lakdawala NK, Cadrin-Tourigny J, Targetti M, Olivotto I, Graziosi M, Cox M, Biagini E, Charron P, Compagnucci P, Casella M, Conte G, Tondo C, Yazdani M, Ware JS, Ware JS, Prasad SK, Calò L, Smith ED, Helms AS, Hespe S, Ingles J, Tandri H, Ader F, Peretto G, Peters S, Horton A, Yao J, Schulze-Bahr E, Dittman S, Carruth ED, Young K, Qureshi M, Haggerty C, Parikh VN, Taylor M, Mestroni L, Wilde A, Sinagra G, Merlo M, Gandjbakhch E, van Tintelen JP, Te Riele ASJM, Elliott P, Calkins H, Wu KC, James CA.   +62 more
europepmc   +2 more sources

Genetic inactivation of β-catenin is salubrious whereas its activation is deleterious in desmoplakin cardiomyopathy.

Cardiovascular Research, 2023
AIM Mutations in the DSP gene encoding desmoplakin, a constituent of the desmosomes at the intercalated discs (IDs), cause a phenotype that spans arrhythmogenic cardiomyopathy (ACM) and dilated cardiomyopathy (DCM).
Melis Olcum, S. Fan, L. Rouhi, Sirisha M Cheedipudi, Ben Cathcart, H. Jeong, Zhongming Zhao, Priyatansh Gurha, A. Marian   +8 more
semanticscholar   +1 more source

Left‐dominant arrhythmogenic cardiomyopathy due to desmoplakin mutation: a case report

ESC Heart Failure, 2023
The case of a 49‐year‐old man with acute onset of heart failure is presented. The initial work‐up showed a dilated cardiomyopathy with severely reduced left ventricular ejection fraction.
Gustavo A Lemus Barrios, J. Lopez-Lopez, Stephany Barbosa-Balaguera, Alejandro Mariño Correa   +3 more
semanticscholar   +1 more source