Results 51 to 60 of about 9,938 (215)

Case Report: A novel desmoplakin mutation in a taiwanese woman with familial dilated cardiomyopathy that necessitated heart transplantation

Frontiers in Genetics, 2022
Around one-third of patients diagnosed with idiopathic dilated cardiomyopathy (DCM) turn out to be familial cases, in only a few of which the identification of a pathogenic/likely pathogenic variant could be achieved. Cardiomyopathy caused by desmoplakin
Yi-Han Chang, Yi-Han Chang, Yi-Han Chang, Pei Lin, Jia-Ling Lin, Jia-Ling Lin, Hsin-Yu Huang, Chao-Kai Hsu, Chao-Kai Hsu, Chao-Kai Hsu, Chih-Hsin Hsu, Chih-Hsin Hsu   +11 more
doaj   +1 more source

Arrhythmogenic right ventricular cardiomyopathy associated with severe left ventricular involvement in a cat. [PDF]

, 2009
An 8-year-old, 4 kg, intact female, domestic shorthaired cat was referred for tachypnea and pleural effusion. A 24-h Holter recording showed numerous polymorphic ventricular premature complexes with left and right bundle branch block morphology ...
Basso C, CIARAMELLA, PAOLO, Di Loria A, PIANTEDOSI, DIEGO   +3 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Naxos Disease [PDF]

, 2005
Since 1995, according to the World Health Organisation’s classification of cardiomyopathies, Naxos disease has been considered as the recessive form of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C).1 It is a stereotype association of
Protonotarios, Nikos, Tsatsopoulou, Adalena   +1 more
core   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Prostaglandin F2 Alpha Triggers the Disruption of Cell Adhesion with Cytokeratin and Vimentin in Bovine Luteal Theca Cells

Animals, 2021
Intermediate filaments (IFs) maintain cell–cell adhesions and are involved in diverse cellular processes such as cytokinesis, cell migration and the maintenance of cell structure.
Sang-Hee Lee, Seunghyung Lee
doaj   +1 more source

Transmembrane protein PERP is a component of tessellate junctions and of other junctional and non-junctional plasma membrane regions in diverse epithelial and epithelium-derived cells [PDF]

, 2013
Protein PERP (p53 apoptosis effector related to PMP-22) is a small (21.4 kDa) transmembrane polypeptide with an amino acid sequence indicative of a tetraspanin character.
AH Christensen, B Holthöfer, B Nguyen, BK Straub, Caecilia Kuhn, Christine Grund, CJ Skerrow, CJ Skerrow, CJ Skerrow, CM Borrmann, D Garrod, D Skerrow, E Delva, EP Parrish, G Gorbsky, GJ Giudice, H Mueller, Hans Heid, HH Wacker, HW Kaiser, J Kartenbeck, J Kartenbeck, J Li, K Akat, K Schwechheimer, L Langbein, L Langbein, LA Staehelin, LD Attardi, LM Godsel, M Barth, M Barth, M Haftek, MG Farquhar, MP Demlehner, MR Marques, MR Marques, P Cowin, P Cowin, P Cowin, P Cowin, P Drochmans, R Duden, R Moll, RA Ihrie, RA Ihrie, RA Ihrie, RA Ihrie, RA Quinlan, Ralf Zimbelmann, RL Dusek, RM Hicks, S Goossens, S Pieperhoff, S Rickelt, S Rickelt, S Rickelt, S Rickelt, S Rickelt, S Rickelt, Stefanie Winter-Simanowski, Steffen Rickelt, VG Beaudry, VG Beaudry, VG Beaudry, Werner W. Franke, WW Franke, WW Franke, WW Franke, WW Franke, WW Franke, WW Franke, Y Horiguchi, Yvette Dörflinger   +73 more
core   +1 more source

Identification of the initial molecular changes in response to circulating angiogenic cells-mediated therapy in critical limb ischemia [PDF]

, 2020
BackgroundCritical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly diminishing oxygen and nutrient supply.
A Carrizzo, A Limbourg, A Schroll, A Taguchi, A Zampetaki, AI Khan, AL Hemdahl, C Hu, C Kalka, C Seignez, C Xia, CH Yoon, D Sukmawati, DH Walter, DM Dunlea, DN Prater, E Chavakis, EB Jude, EC Watson, EE Vaughan, EL Simpson, F Du, F Sabatier, F Vinchi, FG Fowkes, FM Vega, G Cao, G Dragneva, GO Ouma, H Chen, HH Chopra, J Patel, J Rehman, J Zhang, JA Smith, JA Vizcaino, JG Tidball, JK Meisner, JL Anderson, JL Dong, JP Cooke, JX Yang, JY Kim, K Banno, K Funakoshi, L Bao, L Norgren, L Wu, LJ Druhan, M Hassanpour, M Qadura, M Rahmani, M Rigato, MS Conte, N Edwards, P Sangwung, Q Dai, Q Xie, R Donato, R Lara-Hernandez, R Tanaka, RC Savani, RH Lee, RJ Medina, RW Sprengers, S Hazarika, S Janciauskiene, S Nolan, SH Ko, SL Hsu, SM Krishna, SW Kim, T Asahara, UJ Sachs, V Abella, V Weel van, W Song, WC Shen, X Wang, X Zhou, Y Fujita, Y Ye, Z Yang   +82 more
core   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Functional Effects of the TMEM43 Ser358Leu Mutation in the Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy [PDF]

, 2012
Background: The Ser358Leu mutation in TMEM43, encoding an inner nuclear membrane protein, has been implicated in arrhythmogenic right ventricular cardiomyopathy (ARVC). The pathogenetic mechanisms of this mutation are poorly understood.
Ahmad, Ferhaan, McDonough, Barbara Anne, Rajkumar, Revathi, Seidman, Christine Edry, Sembrat, John C   +4 more
core   +5 more sources