Results 21 to 30 of about 1,152 (175)

New insights into desmosome regulation and pemphigus blistering as a desmosome-remodeling disease

Kaohsiung Journal of Medical Sciences, 2013
Desmosomes in keratinocytes are the most important intercellular adhering junctions that provide structural strength for the epidermis. These junctions are connected directly with desmosomal cadherin proteins.
Yasuo Kitajima
doaj   +1 more source

Role of protein kinase C in inhibition of renin release caused by vasoconstrictors [PDF]

, 1986
It was the aim of the present study to get insight into some of the intracellular mechanisms by which the vasoconstrictor hormones angiotensin II (ANG II), arginine vasopressin (AVP), and norepinephrine (NE) inhibit renin release from renal ...
Bauer, C., Bührle, C., Hackenthal, E., Hutter, A., Kurtz, Armin, Nobiling, R., Pfeilschifter, J., Taugner, R.   +7 more
core   +1 more source

Desmoplakin Is Essential for Epidermal Sheet Formation [PDF]

Journal of Investigative Dermatology, 2007
Vasioukhin et al. (2001) provided a dramatic demonstration that the desmosomal cytolinker protein desmoplakin (Dp) is essential for maintaining the integrity of epithelial cell sheets. Furthermore, they show a requirement for desmosomes in efficient maturation of adherens junctions (AJs).
Hopkins, Gemma, Kimura, Tomomi E., Garrod, David R.   +2 more
openaire   +3 more sources

Cardiac Complications of Pregnancy in Desmoplakin Cardiomyopathy

JACC: Case Reports, 2023
We present the course of 4 pregnancies in 3 women with desmoplakin cardiomyopathy, with a focus on changes in left ventricular ejection fraction and N-terminal pro-B-type natriuretic peptide levels from the prepregnancy period through the postpartum period, as well as maternal cardiac, obstetric, and neonatal outcomes. (Level of Difficulty: Advanced.).
Madeline E. Duncan, BS, Anisha Purohit, BS, Katherine E. Economy, MD, Anne Marie Valente, MD, Neal K. Lakdawala, MD   +4 more
openaire   +3 more sources

Subclinical oral involvement in patients with endemic pemphigus foliaceus

Dermatology Practical & Conceptual, 2018
Background: We have described a variant of endemic pemphigus foliaceus (EPF) in El Bagre area known as pemphigus Abreu-Manu. Our previous study suggested that Colombian EPF seemed to react with various plakin family proteins, such as desmoplakins ...
Ana Maria Abreu-Velez, Michael S. Howard, Hector Jose Lambraño Padilla, Sergio Tobon-Arroyave   +3 more
doaj   +1 more source

Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin–EB1 interactions [PDF]

Journal of Cell Biology, 2014
Mechanisms by which microtubule plus ends interact with regions of cell–cell contact during tissue development and morphogenesis are not fully understood. We characterize a previously unreported interaction between the microtubule binding protein end-binding 1 (EB1) and the desmosomal protein desmoplakin (DP), and demonstrate that DP–EB1 interactions ...
Patel, Dipal M., Dubash, Adi D., Kreitzer, Geri, Green, Kathleen J.   +3 more
openaire   +2 more sources

Transmembrane protein PERP is a component of tessellate junctions and of other junctional and non-junctional plasma membrane regions in diverse epithelial and epithelium-derived cells [PDF]

, 2013
Protein PERP (p53 apoptosis effector related to PMP-22) is a small (21.4 kDa) transmembrane polypeptide with an amino acid sequence indicative of a tetraspanin character.
AH Christensen, B Holthöfer, B Nguyen, BK Straub, Caecilia Kuhn, Christine Grund, CJ Skerrow, CJ Skerrow, CJ Skerrow, CM Borrmann, D Garrod, D Skerrow, E Delva, EP Parrish, G Gorbsky, GJ Giudice, H Mueller, Hans Heid, HH Wacker, HW Kaiser, J Kartenbeck, J Kartenbeck, J Li, K Akat, K Schwechheimer, L Langbein, L Langbein, LA Staehelin, LD Attardi, LM Godsel, M Barth, M Barth, M Haftek, MG Farquhar, MP Demlehner, MR Marques, MR Marques, P Cowin, P Cowin, P Cowin, P Cowin, P Drochmans, R Duden, R Moll, RA Ihrie, RA Ihrie, RA Ihrie, RA Ihrie, RA Quinlan, Ralf Zimbelmann, RL Dusek, RM Hicks, S Goossens, S Pieperhoff, S Rickelt, S Rickelt, S Rickelt, S Rickelt, S Rickelt, S Rickelt, Stefanie Winter-Simanowski, Steffen Rickelt, VG Beaudry, VG Beaudry, VG Beaudry, Werner W. Franke, WW Franke, WW Franke, WW Franke, WW Franke, WW Franke, WW Franke, Y Horiguchi, Yvette Dörflinger   +73 more
core   +1 more source

Content-based microarray search using differential expression profiles [PDF]

, 2010
BackgroundWith the expansion of public repositories such as the Gene Expression Omnibus (GEO), we are rapidly cataloging cellular transcriptional responses to diverse experimental conditions. Methods that query these repositories based on gene expression
Jesse M Engreitz, Alexander A Morgan, Joel T Dudley, Rong Chen, Rahul Thathoo, Russ B Altman, Atul J Butte   +6 more
core   +3 more sources

Intracellular Distribution of Desmoplakin in Human Odontoblasts [PDF]

Journal of Histochemistry & Cytochemistry, 2005
Coexpression of desmosomal proteins and vimentin has been reported in a specific mesenchymal phenotype. This study investigated the expression of vimentin-binding desmosomal proteins in human dental pulp fibroblasts (DPF) and odontoblasts. The dental pulp has no cells expressing desmocollin (DSC) 1–3, desmoglein (DSG) 1–3, junction plakoglobin (JUP ...
Yoshihiko, Sawa, Shin-Ichiro, Kuroshima, Yuji, Yamaoka, Shigemitsu, Yoshida   +3 more
openaire   +2 more sources

A novel method for sample preparation of fresh lung cancer tissue for proteomics analysis by tumor cell enrichment and removal of blood contaminants [PDF]

, 2010
Background In-depth proteomics analyses of tumors are frequently biased by the presence of blood components and stromal contamination, which leads to large experimental variation and decreases the proteome coverage.
Luigi De Petris, Maria Pernemalm, Göran Elmberger, Per Bergman, Lotta Orre, Rolf Lewensohn, Janne Lehtiö   +6 more
core   +2 more sources