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Pharmacokinetics of Desmopressin [PDF]
, 1993 In 1967 Zaoral and coworkers synthesized several analogues of vasopressin. One of these derivatives, 1-deamino-8-D-arginine vasopressin (DDAVP, desmopressin), soon became the treatment of choice for diabetes insipidus centralis. DDAVP has a prolonged half-life and a decreased pressor activity when compared with the parent hormone vasopressin (VP). This
M. Köhler, Harris Alan
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DESMOPRESSIN AND ANTIFIBRINOLYTICS
International Anesthesiology Clinics, 1990Desmopressin appears to be a safe and effective hemostatic agent for use during surgery in patients with mild to moderate hemophilia or von Willebrand disease. Uremic patients also benefit from substitution of desmopressin for cryoprecipitate to control bleeding. The highly variable response to desmopressin by individual patients with hemophilia or von
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Regulatory Peptides, 1993
Since it has been synthetized in 1967, desmopressin (Minirin) R or DDAVP (1-desamino-8-Darginine vasopressin) was initially used for its antidiuretic properties [1]. Its capacity to induce an increase in plasma level of procoagulant factor VIII C (FVIII C), von Willebrand factor (vWF) and plasminogen activator was recognized in the following years [2,3]
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Since it has been synthetized in 1967, desmopressin (Minirin) R or DDAVP (1-desamino-8-Darginine vasopressin) was initially used for its antidiuretic properties [1]. Its capacity to induce an increase in plasma level of procoagulant factor VIII C (FVIII C), von Willebrand factor (vWF) and plasminogen activator was recognized in the following years [2,3]
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Desmopressin and super platelets
Blood, 2014In this issue of Blood , Colucci et al provide experimental data supporting the hypothesis that desmopressin (DDAVP) favors the hemostatic process not only by inducing the release of von Willebrand factor (VWF) from endothelial cells, but also by enhancing the procoagulant activity of platelets.[1][
PECCI, ALESSANDRO, BALDUINI, CARLO
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OXYBUTYNIN, DESMOPRESSIN AND ENURESIS
The Journal of Urology, 2001A review of the scarce literature concerning oxybutynin treatment for nocturnal enuresis reveals that its success is greatest when enuresis is combined with daytime incontinence. The renal and bladder related characteristics of children with monosymptomatic enuresis responsive to oxybutynin were evaluated.Renal concentrating capacity and functional ...
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Annals of Internal Medicine, 1988
Excerpt To the editor: Kobrinsky and associates (1) show that patients receiving 1-desamino-8-D-arginine vasopressin (desmopressin) had a decreased blood loss during Harrington rod spinal fusion su...
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Excerpt To the editor: Kobrinsky and associates (1) show that patients receiving 1-desamino-8-D-arginine vasopressin (desmopressin) had a decreased blood loss during Harrington rod spinal fusion su...
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The use of desmopressin in mild hemophilia A
Blood Coagulation & Fibrinolysis, 2010Owing to its ability to raise plasma levels of factor VIII and von Willebrand factor levels, the synthetic vasopressin analogue desmopressin has become the mainstay of treatment for type 1 von Willebrand disease and mild hemophilia A. A long clinical experience with this drug for prevention or treatment of bleedings in these patients has been ...
Franchini M., Zaffanello M., Lippi G.
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Desmopressin (DDAVP) and hemostasis
Annals of Hematology, 1994Desmopressin is a widely used hemostatic drug. It is a synthetic analogue of the natural hormone vasopressin, but, in contrast to vasopressin, it has no pressor activity. The effect is immediate, with two- to sixfold increases in the plasma concentrations of coagulation factor VIII, on Willebrand factor, and tissue plasminogen activator, and increases ...
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Desmopressin in Nocturnal Enuresis
Journal of Urology, 1991The effect of intranasal desmopressin on primary nocturnal enuresis was investigated in a study divided into 2 parts in which the first part was a randomized, double-blind, placebo-controlled cross-over study of 52 Finnish school children 5 to 13 years old.
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Severe hyponatremia due to desmopressin
The Journal of Emergency Medicine, 2006Nasal desmopressin (DDAVP) is a commonly prescribed antidiuretic hormone (ADH) analogue used for treatment of diabetes insipidus, polyuria and nocturnal enuresis. Although it is generally well tolerated, it can cause severe electrolyte imbalance. Numerous reports exist on cases of mild to moderate DDAVP-induced hyponatremia, yet few reports describe ...
Sean O. Henderson, H. Brendan Kelleher
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