Results 41 to 50 of about 499 (176)
Evaluation of Potency and Specificity of Cryptophycin‐Loaded Antibody‐Drug Conjugates
ChemBioChem, Volume 26, Issue 2, January 14, 2025.Cryptophycin‐uD[Dap(Me)], a derivative of the microtubule inhibitor cryptophycin, was equipped with an Mc‐Val‐Cit‐PAB linker to enable conjugation of the toxin to either hinge‐region cysteines or engineered cysteines in THIOMAB variants of trastuzumab. ADCs with DARs of 1.5, 3 and 6 were obtained.
Peter Bitsch +9 more
wiley +1 more source
Entre l’art de l’invisibilité et l’art de la démesure : Marcel Proust caricaturé par Jean Cocteau
Quêtes Littéraires, 2020 Partant d’un dessin de Marcel Proust par Jean Cocteau conçu en 1922 ainsi que d’un essai biographique de Claude Arnaud publié en 2013, l’auteur de l’article présente la relation entre les deux écrivains en référence à la problématique de leur ...
Katarzyna Thiel-Jańczuk
doaj +1 more source
Hochgradig cytotoxische Cryptophycine mit modifiziertem Fragment D zur Konjugation
Angewandte Chemie, Volume 136, Issue 50, December 9, 2024.Cytotoxische Cryptophycine mit diversen konjugierbaren funktionellen Gruppen in Fragment D sind über einen hocheffizienten und skalierbaren Syntheseweg zugänglich. Diese ABC+D Strategie ermöglichte die Synthese einer breiten Bibliothek von Cryptophycinen und führte zu einer quantitativen Struktur‐Wirkungsbeziehung, welche die Synthese der wirksamsten ...
Cedric Dessin +7 more
wiley +1 more source
Highly Cytotoxic Cryptophycin Derivatives with Modification in Unit D for Conjugation
Angewandte Chemie International Edition, Volume 63, Issue 50, December 9, 2024.Cytotoxic cryptophycins with versatile conjugation handles in unit D are accessible by a highly efficient and scalable synthetic route. This ABC+D strategy enabled the creation of a vast array of cryptophycins leading to a quantitative structure activity relationship, allowing for the synthesis of most potent conjugable cryptophycin derivatives being ...
Cedric Dessin +7 more
wiley +1 more source
Il movimento illusorio, l’illusione del movimento
Italies, 2021 L’article porte sur la dimension illusoire de la représentation picturale du mouvement au sein de la théorie artistique de la Renaissance, notamment par le biais de l’analyse du De pictura de Leon Battista Alberti et du Traité de la peinture de Léonard ...
Elena Paroli
doaj
علاقة الشعر بالتشكيل في القصيدة العربية المعاصرة
مجلة الآداب و العلوم الإجتماعية, 2017 تتوجه هذه الدراسة نحو البحث في العلاقة التي تربط الشعر بالتشكيل في القصيدة العربية المعاصرة. وهي علاقة تقوم على رؤية فنية جمالية، جعلت القصيدة المعاصرة منفتحة على إمكانات جديدة، واحتمالات دلالية واسعة؛ تمتزج فيها التجربة الذاتية بالممارسة الفنية. وقد كشف
طارق فتوح
doaj
In the attic of dreams. The personal archives of the father of paradoxical sleep
Journal of the History of the Behavioral Sciences, Volume 60, Issue 4, Fall 2024.Abstract Michel Jouvet (1925–2017) is one of the most important figures in the contemporary history of the neuroscience of sleep and dreams, and one of the most awarded French researchers of the last century. Yet this former CNRS gold medalist and winner of the Cino Del Duca World Prize remains little known—not to say unknown—outside the field of sleep
Michael Roelli
wiley +1 more source
Boreal ecopoetics: Christian Dotremont's site‐specific writing in Sápmi
Orbis Litterarum, Volume 79, Issue 3, Page 264-279, June 2024.Abstract Northern Fennoscandia entered Christian Dotremont's (1922–1979) imagination in 1956. The Belgian avant‐gardist was comfortable in Central‐European artistic milieus through his involvement in CoBrA (1948–1951), but a total of 12 journeys to Sápmi between 1956 and 1978 had a profound effect on his creative work, especially the logograms he is ...
Sami Sjöberg
wiley +1 more source
Topological recursion for Kadomtsev–Petviashvili tau functions of hypergeometric type
Journal of the London Mathematical Society, Volume 109, Issue 6, June 2024.Abstract We study the n$n$‐point differentials corresponding to Kadomtsev–Petviashvili (KP) tau functions of hypergeometric type (also known as Orlov–Scherbin partition functions), with an emphasis on their ℏ2$\hbar ^2$‐deformations and expansions.
Boris Bychkov +3 more
wiley +1 more source
Dessins de territoires / territoires du dessin
Calenda, 2020 Le dessin contemporain s’émancipe du point, de la ligne, du plan pour prendre corps dans une nouvelle écologie de l’image. Du tracé de contour à l’intention - dans le sillage des acceptions du disegno de la Renaissance - il entraîne avec lui des représentations inédites du monde, de son exploitation et de ses possibles.
openaire +1 more source