Results 91 to 100 of about 483,601 (346)

Destination brand authenticity to destination brand engagement in tourism destination

open access: yesTechnium Social Sciences Journal
This study examines Destination Brand Engagement (DBE) in the context of tourism primarily focusing on its outcomes rather than its antecedents. This study differs from previous studies in examines the impact of destination-centric drivers and tourist-centric perspectives.
Intan Widuri Sakti   +2 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Les conditions d’une relation bénéfique entre tourisme et événementiel : Le cas de Deauville, station balnéaire normande

open access: yesTéoros, 2013
De nombreuses collectivités territoriales font le choix, depuis quelques années, de développer une politique événementielle. L’objectif de cet article est de s’interroger sur la pertinence d’une telle stratégie de développement économique, c’est-à-dire ...
Nathalie Alexandre-Bourhis   +2 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Le haut-lieu touristique

open access: yesTéoros, 2011
Dans une approche géographique du tourisme, la destination touristique signifie un lieu ou un espace promu, reconnu et élu suggérant aux individus d’échapper aux contraintes par le moyen d’une mobilité touristique.
Jérôme Piriou
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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