Results 51 to 60 of about 21,269 (216)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Re-modelling Muslim-friendly tourism value chain ecosystem: the case study of West Sumatera, Indonesia

Cogent Social Sciences
The development of Muslim-friendly tourism destinations is an effort to differentiate products and the tourism market amidst the aggressive growth of global tourism.
Anang Sutono, Sumaryadi, Wisnu Rahtomo, Faisal Fahdian Puksi, Odang Permana   +4 more
doaj   +1 more source

ROLE OF SOCIAL MEDIA AS A CATALYST FOR SUSTAINABLE TOURISM DEVELOPMENT IN CALABAR METROPOLIS, NIGERIA [PDF]

Geo Journal of Tourism and Geosites
This study investigates the role of social media in tourism development in Calabar, Nigeria, emphasizing its influence on image building, destination promotion, and information dissemination.
Ukwetang John OKPA, Lilian Anwulika OKORO, Mbaze Ebock Vivian ARREY, Patrick Awok MBUM, Udeme Akaninyene UMO, Grace Michael INA H, Emmanuel Nnamdi NWOBU, Hope Amba NEJI, Okon Dorathy EFFIOM, Gabriel Tanjo ABUMBE, Christiana Aloye USHIE, Agbor Cassidy ETTA, Daniel Daniel JAMES, Ayuk Awunghe ACHU, Eja Eja IWARA *   +14 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Is online learning effective for practice-based tourism courses? A constructive learning approach

Tourism and Hospitality Management
Purpose – The aim of this paper is to 1) measure the effectiveness of online learning in practise-based tourism courses, 2) identify the factors that influence the effectiveness of online learning and 3) propose strategies to encourage tourism students
Ilham Junaid, Marianna Sigala
doaj   +1 more source

Instagrammable Destinations as “Whatever” Destinations

Svetovi: revija za etnologijo, antropologijo in folkloristiko
To be Instagrammable is to be caught in a loop of seeing and being seen – a loop that stretches across screens and through bodies, binding places like Telašćica Nature Park in Croatia to the affective economies of visibility. Drawing on Jodi Dean’s concept of communicative capitalism, this paper explores how the Instagrammable aesthetic transforms ...
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source