Results 101 to 110 of about 302,461 (314)

Destination brand authenticity to destination brand engagement in tourism destination

open access: yesTechnium Social Sciences Journal
This study examines Destination Brand Engagement (DBE) in the context of tourism primarily focusing on its outcomes rather than its antecedents. This study differs from previous studies in examines the impact of destination-centric drivers and tourist-centric perspectives.
Intan Widuri Sakti   +2 more
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Le haut-lieu touristique

open access: yesTéoros, 2011
Dans une approche géographique du tourisme, la destination touristique signifie un lieu ou un espace promu, reconnu et élu suggérant aux individus d’échapper aux contraintes par le moyen d’une mobilité touristique.
Jérôme Piriou
doaj  

Instagrammable Destinations as “Whatever” Destinations

open access: yesSvetovi: revija za etnologijo, antropologijo in folkloristiko
To be Instagrammable is to be caught in a loop of seeing and being seen – a loop that stretches across screens and through bodies, binding places like Telašćica Nature Park in Croatia to the affective economies of visibility. Drawing on Jodi Dean’s concept of communicative capitalism, this paper explores how the Instagrammable aesthetic transforms ...
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Advances in tourism destination marketing: Managing networks

open access: yes, 2009
This volume provides original insight into the operational opportunities, challenges and constraints in managing Tourism Destination Marketing. It explores how the various tourist destination systems including tourist, places (as seen by the tourist ...
Kozak, M., Andreu, L., Gnoth, J.
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Unmanageable Tourism Destination Brands?

open access: yes
Increasingly researchers and practitioners adopt branding to build and manage tourism destination images. However, we have yet to ask the question: Is it pos-sible to build and/or manage destination brands? This crucial question is ad-dressed by means of:
Bodil Stilling Blichfeldt
core   +1 more source

Traveloregon.com website user and conversion study: final report of findings

open access: yes, 2020
research prepared for Travel Oregon by: Destination Analysts.Title from PDF cover (viewed on February 17, 2021).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

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