Results 31 to 40 of about 122,383 (265)
Frontiers in Neurology, 2020 Background: The sequence effect (SE), referring to step-to-step reduction in amplitude, is considered to lead to freezing of gait (FOG) in Parkinson's disease (PD). Visual cues may alleviate SE and help reduce freezing episodes.
Shan-Shan Cao +4 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Technology Innovation Management Review, 2020 This paper aims to conceptually develop a business model typology in tourism. It focuses on digitalization and destination location as important contextual factors when developing the typology.
Gabriel Linton, Christina Öberg
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Beyond Tourism: The Ways of Salatiga Culinary Business People to Survive Covid-19
Indonesian Journal of Tourism and LeisureDuring the COVID-19 pandemic, the sustainability of tourism-related livelihoods was significantly impacted. Tourism-related SMEs, including culinary businesses, have strived to find ways to endure the pandemic.
Rio Giovano Setiawan +1 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Will Generation Z Use ChatGPT for Tourism Recommendations?
Tourism and Hospitality ManagementPurpose – This research note examines Generation Z’s acceptance of ChatGPT as a Tourism Recommender System, to better understand whether they will use it for a tourism recommendation, and the factors influencing their acceptance.
Anom Hery SUASAPHA
doaj +1 more source
Jàmbá, 2021 Many variables influence visitors’ destination choices, for example, affordability, attractions, health and safety, and expectancies. Amongst the indirect influences in destination choice by tourists, climate change is perhaps the greatest factor because
Nduduzo A. Ngxongo
doaj +1 more source