Results 111 to 120 of about 302,461 (314)
The 2016 St. Gallen Consensus on Advances in Destination Management
, 2018 This article communicates the main insights of the third Biennial Forum on Advances in Destination Management (ADM), held in Vail, Colorado (USA). The substance of scholars’ and practitioners’ discussions can be divided into five topical domains: (1 ...
Christian Laesser +5 more
core +1 more source
Country Branding and Country Image: Insights, Challenges and Prospects. The Case of Estonia
Baltic Journal of European studies, 2014 Gaining understanding about customers ’mindset and information on their experiences is a precondition for the formulation of an effective country branding strategy.
Same Siiri +1 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
THE ROLE OF RESORT PLANNING IN SUSTAINING TOURIST DESTINATION IMAGE
The environmental quality is recognized to be an important factor while making decisions upon the destination to visit. The image of the resort will likely to be more realistic but also complex after the tourists’ visit.
Ozdemir, Gocke
core +1 more source
Performance evaluation framework for destination management organisations: managers' perspectives.
, 2014 This study aims to develop a performance evaluation framework for Destination Management Organisations (DMOs). Although tourism researchers (Ritchie and Crouch 2005; Pike 2005; Bornhorst et al.
Spyriadis, Thanasis
core
, 2018 Emotional reactions to marketing stimuli are essential to tourist destination marketing, yet difficult to validly measure. A neuromarketing experiment was peformed to establish whether brain event-related potentials (ERPs), elicited by destination photos,
Bastiaansen, MCM +13 more
core +1 more source
Ekonomika Poljoprivrede (1979)Gastronomy has the power to attract tourists as a tourist attraction and make them loyal to it. Toward discussing their research, the authors first base their hypothesis on the argument that traditional gastronomy creates loyalty toward the destination.
Tamara Vujić +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source