Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
An investigation of destination attributes and service quality of tourism in Amhara Region, Ethiopia [PDF]
The general objective of this study was to examine tourist evaluation of the destination attributes and how these associate with tourists’ satisfaction in Amhara Region, Ethiopia.
Sisay Haile +2 more
doaj
Factors Affecting Malaysia Tourists’ Destination Loyalty Behavior: A Case Study of Hatyai, Thailand
Retaining the loyal visitors to revisit is highly crucial for generating the revenue in tourism destination as well as reducing the marketing expenses, this empirical study has been designed to primarily explore factors that motivate Malaysia tourists ...
chutima wangbenmad
doaj +1 more source
An Evaluation of Wildlife Tourism Destinations’ Attributes, Overall Satisfaction and Revisit Intentions: A Tourist Guides’ Perspective [PDF]
This study developed and tested a model integrating associations of tourist guides, wildlife tourism destination attributes, overall satisfaction and revisit intentions.
George Ariya +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
DESTINATION MARKETING TO IMPROVE DOMESTIC TOURISTS’ RETURN INTENTION
Purpose: This study aims to analyze tourist return intention through destination attribute (attraction, accessibility, and amenities), promotion, and destination image mediated by tourist satisfaction.
Filda Rahmiati, Andrean Winata
doaj +1 more source
Modeling users' satisfaction and visit intention using AI-based chatbots.
AI-based chatbots are an emerging technology disrupting the tourism industry. Although chatbots have received increasing attention, there is little evidence of their impact on tourists' decisions to visit a destination.
Miguel Orden-Mejía +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Generation Y and Z Destination Attractiveness Attributes
The purpose of this study was to explore Generation Y and Z perceptions of destination attractiveness (DA) and their propensity to visit a destination. The objectives of this research include examining which destination attractiveness factors are critical to Generation Y and Z tourists and to compare and contrast Generation Y and Z attractiveness ...
Godwin-Charles Ogbeide +1 more
openaire +2 more sources

