Results 91 to 100 of about 169,635 (293)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Brand destination loyalty: the antecedents of destination brand experience
Cogent Business & ManagementThe Indonesian government has developed ten super priority areas to serve as destinations for domestic and international tourists. Tourism marketing is carried out by applying the destination brand experience, which confirms the authenticity of the ...
Endang Sulistya Rini +2 more
doaj +1 more source
The legend of the RMA: A trilogy [PDF]
, 2003 In this presentation the author paints the conflict of people versus nature in light of the RMA, and go on to look at the repercussions of this through not only the plans that were prepared under this controversial legislation, but also their ...
Ericksen, Neil
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Cogent EducationAs China emerges as a prominent destination for international higher education, universities globally are forming partnerships with Chinese institutions.
Huili Si, Stephen Rayner
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Exploring the Role of Destination Resilience Plans in Promoting Tourism: A Literature Review
JPAIRThe study investigates the critical importance of destination resilience in enhancing tourism, particularly in the wake of challenges such as the COVID-19 pandemic.
Cristina Caluza
doaj +1 more source
Rural migration in sub-Saharan Africa: Patterns, drivers and relation to structural transformation [PDF]
, 2019 Sub-Saharan Africa has a long history of internal and international migratory movements. Migration patterns and dynamics from, to and between rural areas are profoundly differentiated across regions, and flows have considerably evolved over time.
Belebema, Michael N. +8 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The effects of migration on children's activities in households at origin: Evidence from Senegal [PDF]
This paper examines the repercussions of international migration on children?s time allocation in households at origin. We focus on children of age 7 to 12 and distinguish three activities: market work, French school attendance, and enrollment in Medersa
CISSÉ Fatou, FAYE Ousmane
core +1 more source