HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
The mediation of perceived risk's impact on destination image and travel intention: An empirical study of Chengdu, China during COVID-19. [PDF]
PLoS One, 2022 Jiang X, Qin J, Gao J, Gossage MG.
europepmc +1 more source
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
Do you dare to travel to China? An examination of China's destination image amid the COVID-19. [PDF]
Tour Manag Perspect, 2021 Lu Q, Atadil HA.
europepmc +1 more source
VIENNA`S BRANDING CAMPAIGN – STRATEGIC OPTION FOR DEVELOPING AUSTRIA`S CAPITAL IN A TOP TOURISM DESTINATION [PDF]
The fact that Vienna is an attractive tourist destination, well known internationally is undeniable. With its imperial splendour and remarkable cultural image, Vienna has become, in the recent years, an attractive tourist destination, reaching in 2010 ...
Razvan Andrei CORBOS +1 more
core
Do destination brands really have a personality? A comparison of two coastal tourism destinations in Australia [PDF]
, 2005 According to Morgan et al (2003), the need for destinations to portray a unique identity is more critical than ever yet much of destination advertising remains blue seas, cloudless skies and endless golden beaches with less than memorable tag lines. They
Benckendorff, P. +2 more
core
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Outbound medical tourists: The interplay of perceived quality, length of stay, group-size, post-visit destination image and revisit intention. [PDF]
PLoS One, 2022 Rahman I, Martin DS, Liu S.
europepmc +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source