Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
The Role of Place Attachment as a Mediator Between Destination Image and Revisit Intention
Tourism is one of the sectors that contributes to Indonesia's economic growth. The tourism sector needs to increase the number of tourist visits by improving the good image of visitors so that they are interested in visiting again. Factors that influence
Agung Budiatmo, Sari Listyorini
doaj +1 more source
Place branding and the representation of people at work: Exploring issues of tourism imagery and migrant labour in the Republic of Ireland [PDF]
This paper addresses destination brand image in tourism marketing and assesses the contribution of tourism ' s workforce to such image and branding, considering the role that employees play in visitors ' interpretation of their experience of destination ...
Baum, T.G., Devine, F., Hearns, N.
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
In recent years, many has begun to doubt the continued existence of Bali’s nature and culture in shaping its destination image. The current research was conducted to confirm the existence of culture and nature as the determining factors of Bali’s image ...
I Gusti Bagus Rai Utama
doaj
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
A study of cultural distance, eWOM and perceived risk in shaping higher education students' destination image and future travel plan [PDF]
Purpose – This study aims to predict the effect of cultural distance, perceived risk and electronic word of mouth (eWOM) on higher education institutes' students' destination image.
Xia Yang +2 more
doaj +1 more source
Destination Image Through TripAdvisor´s Reviews Analysis
Tourists’ satisfaction and motivation have been recurrent themes in tourism literature. In recent years these themes have also been addressed based on online evaluations carried out by tourists, TripAdvisor is one of the most used sites. In this context, this study aims to analyse the image of Bragança's tourism destination based on TripAdvisor reviews
Elaine Scalabrini +3 more
openaire +2 more sources

