Results 71 to 80 of about 27,430 (257)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Relevance for tourist visiting decisions – destination branding vs destination image: Case study from Lariti Beach, Bima Regency

Tourism
Today, there are disciplines that concentrate on tourism, some of which highlight a tourist’s visiting decision; this is not only associated with the brand or reputation of a destination but also its image. From this premise, this study aims to find the
Saida Zainurossalamia ZA, Irsan Tricahyadinata   +1 more
doaj   +1 more source

THE IMPACT OF AGROTOURISM DESTINATION IMAGE ON TOURIST’S LOYALTY IN ZAGHOUAN, TUNISIA: MODERATING ROLE OF VISIT’S EXPERIENCE [PDF]

Geo Journal of Tourism and Geosites
This study tests the influence of destination image on loyalty. It also examines the moderation effect of visitors’ experiences in the link between the two main components of destination image and loyalty.
Abu Elnasr E. SOBAIH, Hassane GHARBI, Imed ZAIEM, Nadir ALIANE   +3 more
doaj   +1 more source

Gastronomic Experience and Consumer Behavior: Analyzing the Influence on Destination Image. [PDF]

Foods, 2023
Kovalenko A, Dias Á, Pereira L, Simões A.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Modelling the Image Research of a Tourism Destination

Amfiteatru Economic, 2014
The problematic area of the tourism destination image has a high expansion in marketing, the efforts of its conceptualization and phenomenalism being remarkable among specialists.
Nicolae Teodorescu, Ion Pârgaru, Aurelia-Felicia Stancioiu, Elena Matei , Andreea Botos   +4 more
doaj  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The formation of multi-destination image: A study of China's Greater Bay Area. [PDF]

Front Psychol, 2022
Duan X, Lai IKW.
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source