Results 51 to 60 of about 11,518,650 (281)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Plant-based diets and destination image: A holistic approach [PDF]

open access: yes, 2021
A growing number of individuals in contemporary society follow a plant-based diet due to discourse and debates around the environmental impacts, the treatment of animals and health-related issues associated with animal agriculture. At the same time, food
Guachalla, A.
core   +1 more source

The Role of Place Attachment as a Mediator Between Destination Image and Revisit Intention

open access: yesInternational Journal of Applied Research in Business and Management
Tourism is one of the sectors that contributes to Indonesia's economic growth. The tourism sector needs to increase the number of tourist visits by improving the good image of visitors so that they are interested in visiting again. Factors that influence
Agung Budiatmo, Sari Listyorini
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Keunikan Budaya dan Keindahan Alam sebagai Citra Destinasi Bali menurut Wisatawan Australia Lanjut Usia

open access: yesJurnal Kajian Bali (Journal of Bali Studies), 2016
In recent years, many has begun to doubt the continued existence of Bali’s nature and culture in shaping its destination image. The current research was conducted to confirm the existence of culture and nature as the determining factors of Bali’s image ...
I Gusti Bagus Rai Utama
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Cyprus' image—a sun and sea destination—as a detrimental factor to seasonal fluctuations. Exploration into motivational factors for holidaying in Cyprus [PDF]

open access: yes, 2013
Cyprus is established as a summer destination. To aid the destination in developing its winter season as well, this research uses a qualitative inductive approach to explore the tourists’ current image of the island and their motivations of visiting it ...
Koutra, Christina, Karyopouli, S.
core   +1 more source

Marketing of a destination: Jordan as a case study [PDF]

open access: yes, 2007
This study investigates the internal and external environmental factors that affect destination marketing in Jordan and the use of the destination marketing concept by tourism companies in Jordan.
Alhroot, Abdel-Hafiz Hussein Jaddou
core   +4 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

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