Results 51 to 60 of about 27,430 (257)

The Impact of a Local Well-Being Philosophy on Revisit Intentions to Bali Among Digital Nomads

Tourism and Hospitality
The level of success in tourism is gauged by several metrics; however, the most widely used is the level of tourist arrivals. However, this research answered the call for greater investigation of the impacts of qualitative factors and intangible cultural–
Hanugerah Kristiono Liestiandre, Alastair M. Morrison, Ni Nyoman Kerti Yasa, Tjok Gd Raka Sukawati, I. Putu Gde Sukaatmadja   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A study of cultural distance, eWOM and perceived risk in shaping higher education students' destination image and future travel plan [PDF]

Journal of Tourism Futures
Purpose – This study aims to predict the effect of cultural distance, perceived risk and electronic word of mouth (eWOM) on higher education institutes' students' destination image.
Xia Yang, Jihad Mohammad, Farzana Quoquab   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The lure of siren’s song: Exploring the influence of destination song perception on potential tourists’ travel intentions

PLoS ONE, 2023
Tourism destinations are the important research objects of tourism geography. And destination songs, as a media of tourism destination image, play a very important role in it.
Long Wei, Ting Shao, Xinwei Shi, Keqin Ren, Ying Qian   +4 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Examining the Mediating Effect of Destination Image Between Sensory Impression and Behavioral Intention: Empirical Evidence From China World Natural Heritage Sites

SAGE Open
Destination image and sensory impression are crucial to examine the tourist experience and behavioral intention. However, substantial knowledge gaps exist regarding how sensory impressions affect destination images and their mediating role in behavioral ...
Qiwen Zheng, Suraiyati Rahman
doaj   +1 more source

ISLANDS AND DESTINATION IMAGE: THE CASE OF IOS [PDF]

, 2007
This study was conducted to identify the image of Ios as a tourist destination as perceived by the visitors, in order to contribute to the formation of an effective marketing plan. The strengths and weaknesses of the image of Ios were measured and presented, accompanied with a number of recommendations.
Stylidis, Dimitrios, Terzidou, Matina, Terzidis, Konstantinos   +2 more
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source