Results 21 to 30 of about 97,767 (354)

Final results of DESTINY-CRC01 investigating trastuzumab deruxtecan in patients with HER2-expressing metastatic colorectal cancer

Nature Communications, 2023
DESTINY-CRC01 (NCT03384940) was a multicenter, open-label, phase 2 trial assessing the efficacy and safety of trastuzumab deruxtecan (T-DXd) in patients with HER2-expressing metastatic colorectal cancer (mCRC) that progressed after ≥2 prior regimens ...
T. Yoshino, M. Di Bartolomeo, K. Raghav, T. Masuishi, F. Loupakis, H. Kawakami, K. Yamaguchi, T. Nishina, Z. Wainberg, E. Élez, Javier Rodríguez, M. Fakih, F. Ciardiello, K. Saxena, Kojiro Kobayashi, E. Bako, Y. Okuda, G. Meinhardt, A. Grothey, S. Siena   +19 more
semanticscholar   +1 more source

Trastuzumab Deruxtecan in Previously Treated Patients With HER2-Positive Metastatic Breast Cancer: Updated Survival Results From a Phase 2 Trial (DESTINY-Breast01)

Annals of Oncology, 2023
Background Primary analysis of the multicenter, open-label, single-arm, phase 2 DESTINY-Breast01 trial (median follow-up, 11.1 months) demonstrated durable antitumor activity with trastuzumab deruxtecan (T-DXd) in patients with human epidermal growth ...
C. Saura, S. Modi, I. Krop, Y. Park, S. Kim, K. Tamura, H. Iwata, J. Tsurutani, J. Sohn, E. Mathias, Y. Liu, J. Cathcart, J. Singh, T. Yamashita   +13 more
semanticscholar   +1 more source

Polarity Is Destiny [PDF]

Cell, 2009
The GTPase Cdc42 specifies polarity in various biological processes. Kesavan et al. (2009) now demonstrate that Cdc42 also regulates epithelial cell polarity in the developing mouse pancreas, where it is required for tubule formation and maintenance.
Cai, Liang, Mostov, Keith
openaire   +2 more sources

Din Eğitimi Açısından Doğal Afetlerle Başa Çıkmada Temel Kur’anî Kavramlar

Türkiye Din Eğitimi Araştırmaları Dergisi, 2023
Afetler, tarih boyunca insanlığın öncelikli konularından biri olmuştur. Bu afetler, gerçekleşeceği yer, zaman ve şiddeti belirsiz, can ve mal kaybına neden olan olaylar olarak bilinir.
Süleyman Gümrükçüoğlu
doaj   +1 more source

Patient-reported outcomes and hospitalization data in patients with HER2-positive metastatic breast cancer receiving trastuzumab deruxtecan or trastuzumab emtansine in the phase 3 DESTINY-Breast03 study.

Annals of Oncology, 2023
BACKGROUND In the DESTINY-Breast03 clinical trial, trastuzumab deruxtecan (T-DXd) showed superior progression-free survival and overall survival versus trastuzumab emtansine (T-DM1) and manageable safety in patients with HER2-positive (HER2+) metastatic ...
G. Curigliano, K. Dunton, M. Rosenlund, M. Janek, J. Cathcart, Y. Liu, P. Fasching, H. Iwata   +7 more
semanticscholar   +1 more source

Cult Vocabulary in Buryat Traditional Culture: Semantics, Genesis, and Aspects of Functioning

Oriental Studies, 2020
One of the most promising aspects of research into the cult tradition of the Buryats is the study of the concepts of ‘cult’ and ‘sacred’. Goals. The paper aims to analyze the issue of applying the category of ‘sacred’ developed by European religious ...
Eleonora A. Nemanova
doaj   +1 more source

Cost-effectiveness analysis of trastuzumab deruxtecan in patients with HER2-low advanced breast cancer based on DESTINY-Breast04

Frontiers in Public Health, 2023
Background and purpose Breast cancer is a rapidly raising healthcare problem worldwide. DESTINY-Breast04 demonstrated that trastuzumab deruxtecan (T-Dxd) had a survival advantage comparing to the physician's choice of chemotherapy for patients with HER2 ...
M. Zhan, Zijia Huang, Ting Xu, Xinyi Xu, Hanrui Zheng, Feng Wu   +5 more
semanticscholar   +1 more source

Trastuzumab Deruxtecan in HER2-Positive Metastatic Breast Cancer Patients with Brain Metastases: A DESTINY-Breast01 Subgroup Analysis

Cancer Discovery, 2022
This subgroup analysis of patients with HER2-positive breast cancer with a history of brain metastases from DESTINY-Breast01 demonstrated the strong clinical activity of trastuzumab deruxtecan (T-DXd) in this patient population, warranting continued ...
G. Jerusalem, Yeon-Hee Park, S. Hurvitz, S. Modi, F. André, I. Krop, X. Gonzalez-Farré, Benoit You, C. Saura, Sung-Bae Kim, C. Osborne, R. Murthy, L. Gianni, T. Takano, Yali Liu, J. Cathcart, Caleb Lee, Christophe Perrin   +17 more
semanticscholar   +1 more source

Kelâm ve Tasavvuf Açısından Kadere İman-Tevekkül İlişkisi

Kader, 2020
Bu makalenin amacı kadere iman ve tevekkül ilişkisini kelâm ve tasavvuf disiplinleri açısından incelemektir. Tevekkül İslâm ahlâkında imanın olumlu özelliklerinden birisi olarak kabul edilir.
Mustafa Ünverdi
doaj   +1 more source

Death as Initiation (Rebirth) [PDF]

مجله مطالعات ایرانی, 2016
Human existence lies in the heart of existentialism. This school of thought deals with the challenges of human responsibility and the possibility of improvement and progress of human life.
Mohsen Botlab Akbarabadi, Masoumeh Barsam   +1 more
doaj   +1 more source