Results 41 to 50 of about 67,340 (296)

Assessing Tourism Potential and Ecotourism Attractions of Annapurna Base Camp Nepal through an Appreciative Inquiry Approach [PDF]

open access: yesJournal of Tourism, Sustainability and Well-being
Nature-based tourism such as trekking and mountaineering has gained popularity in recent years due to the demand for experience-based tourism. Adventure tourism is one of the mainstays of Nepali economy and a major source of revenue. Trekking has brought
Pratik Bhattarai, Krishna Rawal, Anup KC
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Qada’ Dan Qadar Perspektif Al-Qur’an Hadits dan Implikasinya Terhadap Pendidikan Agama Islam

open access: yesJ-PAI: Jurnal Pendidikan Agama Islam, 2020
Something that happens to humans is that God's will is very true, but every human being also has his own will. So that in education students can change learning outcomes by continuing to learn and make a change of changes that will run in harmony and ...
J. Nabiel Aha Putra   +1 more
doaj   +1 more source

On Destiny

open access: yesDIALOGO, 2022
If some intelligence underlies the universe, as is suggested by a host of modern-day considerations, then why does not that intelligence intervene to allay the oft-horrible destinies that are the lot of so many sentient beings?
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

THE CONCEPT OF FATE IN AMERICAN SCIENCE FICTION LITERATURE

open access: yesNovìtnâ Osvìta, 2016
The present article is dedicated to the problem of the concept of fate functioning in the American picture of the world. The aim of the article is to investigate the concept sphere of fate in American science-fiction literature.
Yana Gryshchenko
doaj   +1 more source

A Comparative Study of the Zoroastrian [PDF]

open access: yesمجله مطالعات ایرانی, 2016
Human existence lies in the heart of existentialism. This school of thought deals with the challenges of human responsibility and the possibility of improvement and progress of human life.
Sahar Pourjam, Abolghasem Dadvar
doaj   +1 more source

Allah’ın Kulların İrâdî Fiillerini Önceden Bilmediğini Öne Süren Görüşün Tefsir İlmi Açısından Kritiği

open access: yesCumhuriyet İlahiyat Dergisi, 2023
Kur'ân-ı Kerim'deki bazı ayetler ilk bakışta Cenâb-ı Hakk'ın bir takım şeyleri sonradan bilmekte olduğu şeklinde anlaşılabilecek yapıdadır. Bu gibi ayetlerden hareketle Cenâb-ı Hakk'ın kulların irâdî fiillerini sonradan bildiği öne sürülmüştür.
Fatih Çelikel
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy